DegronMD

Uniprot ID: Q96SM3

Source protein: Probable carboxypeptidase X1

Source gene: CPXM1

Class: DEG_APCC_DBOX_1

Location: 722:730

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8554

ASA_SCORE: 100.3444

COIL: 0.1514

CONS_SCORE: 0.4397

DSS_SCORE: 0.6574

HELIX: 0.8577

FCONS_SCORE: 1.1535

RIG_SCORE: 0.7637

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P719S	TCGA-56-A62T	LUSC	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	0.25
p.P719S	DO219144	LUSC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.25
p.R730M	TCGA-60-2719	LUSC	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	0.7521
p.R730M	DO27453	LUSC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.7521
p.A716T	TCGA-AX-A2HC	UCEC	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	0.1667
p.A716T	DO41572	UCEC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.1667
p.L726P	TCGA-EJ-8469	PRAD	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	0.7582
p.L726P	DO46810	PRAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.7582
p.D721N	TCGA-GF-A6C9	SKCM	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	0.3056
p.D721N	DO51254	SKCM	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.3056
p.L722R	TCGA-HU-8245	STAD	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	0.7316
p.L722R	DO47929	STAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.7316
p.R728Q	DO229377	BTCA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.6218
p.R728Q	DO50412	ESAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.6218
p.R728W	DO50434	ESAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.7523
p.A713E	DO229028	LICA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.0833
p.R723C	DO23356	LINC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.8301
p.R723C	DO50305	PAEN	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.8301
p.R725C	DO49200	PACA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.719
p.R725C	SIDM00806	Osteosarcoma	GDSC	LRRRLERLR	DEG_APCC_DBOX_1	0.719
p.R725C	HOS	bone	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	0.719
p.R725H	DO47234	RECA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	0.7133
p.V718L	SIDM00333	Endometrial Carcinoma	GDSC	LRRRLERLR	DEG_APCC_DBOX_1	0.2222
p.V718L	ACH-000988	Endometrial/Uterine Cancer	CCLE	LRRRLERLR	DEG_APCC_DBOX_1	0.2222
p.V718L	MFE-319	endometrium	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	0.2222
p.K733E	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LRRRLERLR	DEG_APCC_DBOX_1	0.3611
p.K733E	ACH-000869	Lung Cancer	CCLE	LRRRLERLR	DEG_APCC_DBOX_1	0.3611
p.K733E	NCI-H1568	lung	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	0.3611
p.E727G	ACH-000989	Colon/Colorectal Cancer	CCLE	LRRRLERLR	DEG_APCC_DBOX_1	0.6087
p.E727G	SNU-175	large_intestine	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	0.6087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRRLERLR

Degron related mutations and impact score

Drug responses associated with CPXM1 mutations

All proteins holding degron of LRRRLERLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SM3	Probable carboxypeptidase X1	DEG_APCC_DBOX_1	722:730	LRRRLERLR	APC,CDC20,FZR1	0.8554	More...