DegronMD - Q96SM3(CPXM1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P719S	TCGA-56-A62T	LUSC	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.25
p.P719S	DO219144	LUSC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.25
p.R730M	TCGA-60-2719	LUSC	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7521
p.R730M	DO27453	LUSC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7521
p.K80N	TCGA-AG-3892	READ	TCGA	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation substituting flanking lysine	0.25
p.K80N	TCGA-HU-8238	STAD	TCGA	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation substituting flanking lysine	0.25
p.K80N	DO36394	READ	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation substituting flanking lysine	0.25
p.K80N	DO47944	STAD	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation substituting flanking lysine	0.25
p.E109D	TCGA-AP-A0LM	UCEC	TCGA	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.1944
p.E109D	DO43306	UCEC	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.1944
p.A716T	TCGA-AX-A2HC	UCEC	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1667
p.A716T	DO41572	UCEC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1667
p.R86C	TCGA-BR-7715	STAD	TCGA	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.R86C	DO233743	GACA	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.R86C	DO38679	STAD	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.R86C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.R86C	ACH-000605	Esophageal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.R86C	TE-6	oesophagus	COSMIC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.P89S	TCGA-D6-6516	HNSC	TCGA	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.6752
p.P89S	DO15623	HNSC	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.6752
p.V91M	TCGA-DC-6683	READ	TCGA	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.6097
p.V91M	DO37018	READ	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.6097
p.L726P	TCGA-EJ-8469	PRAD	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7582
p.L726P	DO46810	PRAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7582
p.D721N	TCGA-GF-A6C9	SKCM	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.3056
p.D721N	DO51254	SKCM	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.3056
p.L722R	TCGA-HU-8245	STAD	TCGA	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7316
p.L722R	DO47929	STAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7316
p.R728Q	DO229377	BTCA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6218
p.R728Q	DO50412	ESAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6218
p.R728W	DO50434	ESAD	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7523
p.R79W	DO234366	ESAD	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.1111
p.A713E	DO229028	LICA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.0833
p.A93D	DO229041	LICA	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.3056
p.A93D	DO229041	LICA	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2222
p.T113K	DO229009	LICA	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.0833
p.R723C	DO23356	LINC	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.8301
p.R723C	DO50305	PAEN	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.8301
p.R725C	DO49200	PACA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.719
p.R725C	SIDM00806	Osteosarcoma	GDSC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.719
p.R725C	HOS	bone	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.719
p.E112D	DO232224	PBCA	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.1111
p.R725H	DO47234	RECA	ICGC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7133
p.P89L	DO228011	SKCA	ICGC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.7582
p.V718L	SIDM00333	Endometrial Carcinoma	GDSC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.V718L	ACH-000988	Endometrial/Uterine Cancer	CCLE	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.V718L	MFE-319	endometrium	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.T88I	SIDM00498	Colorectal Carcinoma	GDSC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.7078
p.T88I	ACH-000970	Colon/Colorectal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.7078
p.T88I	SNU-C5	large intestine	COSMIC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation altering degron motif	0.7078
p.T85S	SIDM00836	Colorectal Carcinoma	GDSC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.2778
p.T85S	ACH-000820	Colon/Colorectal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.2778
p.T85S	SW403	large intestine	COSMIC	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.2778
p.K733E	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation substituting flanking lysine	0.3611
p.K733E	ACH-000869	Lung Cancer	CCLE	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation substituting flanking lysine	0.3611
p.K733E	NCI-H1568	lung	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation substituting flanking lysine	0.3611
p.A108T	SIDM01612	Endometrial Carcinoma	GDSC	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2222
p.A108T	ACH-000946	Endometrial/Uterine Cancer	CCLE	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2222
p.E727G	ACH-000989	Colon/Colorectal Cancer	CCLE	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6087
p.E727G	SNU-175	large intestine	COSMIC	LRRRLERLR	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6087
p.G94R	ACH-001459	Colon/Colorectal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	87:92	Mutation rewiring degron network	0.2778
p.G94R	ACH-001459	Colon/Colorectal Cancer	CCLE	VTPTPAGT	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPXM1

UniProt ID: Q96SM3

Entrez ID: 56265

Protein name: Probable carboxypeptidase X1 (EC 3.4.17.-) (Metallocarboxypeptidase CPX-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPXM1 in