DegronMD

Uniprot ID: Q96SM3

Source protein: Probable carboxypeptidase X1

Source gene: CPXM1

Class: DEG_SCF_FBW7_1

Location: 87:92

E3 ligase: FBXW7

DEGRON score: 0.9286

ASA_SCORE: 99.1333

COIL: 0.9332

CONS_SCORE: 0.3737

DSS_SCORE: 0.499

HELIX: 0.0228

FCONS_SCORE: 1.0652

RIG_SCORE: 0.7503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K80N	TCGA-AG-3892	READ	TCGA	PTPLVT	DEG_SCF_FBW7_1	0.25
p.K80N	TCGA-HU-8238	STAD	TCGA	PTPLVT	DEG_SCF_FBW7_1	0.25
p.K80N	DO36394	READ	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.25
p.K80N	DO47944	STAD	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.25
p.R86C	TCGA-BR-7715	STAD	TCGA	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.R86C	DO233743	GACA	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.R86C	DO38679	STAD	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.R86C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.R86C	ACH-000605	Esophageal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.R86C	TE-6	oesophagus	COSMIC	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.P89S	TCGA-D6-6516	HNSC	TCGA	PTPLVT	DEG_SCF_FBW7_1	0.6752
p.P89S	DO15623	HNSC	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.6752
p.V91M	TCGA-DC-6683	READ	TCGA	PTPLVT	DEG_SCF_FBW7_1	0.6097
p.V91M	DO37018	READ	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.6097
p.R79W	DO234366	ESAD	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.1111
p.A93D	DO229041	LICA	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.3056
p.P89L	DO228011	SKCA	ICGC	PTPLVT	DEG_SCF_FBW7_1	0.7582
p.T88I	SIDM00498	Colorectal Carcinoma	GDSC	PTPLVT	DEG_SCF_FBW7_1	0.7078
p.T88I	ACH-000970	Colon/Colorectal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	0.7078
p.T88I	SNU-C5	large_intestine	COSMIC	PTPLVT	DEG_SCF_FBW7_1	0.7078
p.T85S	SIDM00836	Colorectal Carcinoma	GDSC	PTPLVT	DEG_SCF_FBW7_1	0.2778
p.T85S	ACH-000820	Colon/Colorectal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	0.2778
p.T85S	SW403	large_intestine	COSMIC	PTPLVT	DEG_SCF_FBW7_1	0.2778
p.G94R	ACH-001459	Colon/Colorectal Cancer	CCLE	PTPLVT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SM3	Probable carboxypeptidase X1	DEG_SCF_FBW7_1	87:92	PTPLVT	FBXW7	0.9286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons