DegronMD

Uniprot ID: Q96SM3

Source protein: Probable carboxypeptidase X1

Source gene: CPXM1

Class: DEG_SCF_FBW7_1

Location: 97:104

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 84.95

COIL: 0.9378

CONS_SCORE: 0.3637

DSS_SCORE: 0.6034

HELIX: 0.0209

FCONS_SCORE: 0.983

RIG_SCORE: 0.6765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E109D	TCGA-AP-A0LM	UCEC	TCGA	VTPTPAGT	DEG_SCF_FBW7_1	0.1944
p.E109D	DO43306	UCEC	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	0.1944
p.A93D	DO229041	LICA	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	0.2222
p.T113K	DO229009	LICA	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	0.0833
p.E112D	DO232224	PBCA	ICGC	VTPTPAGT	DEG_SCF_FBW7_1	0.1111
p.A108T	SIDM01612	Endometrial Carcinoma	GDSC	VTPTPAGT	DEG_SCF_FBW7_1	0.2222
p.A108T	ACH-000946	Endometrial/Uterine Cancer	CCLE	VTPTPAGT	DEG_SCF_FBW7_1	0.2222
p.G94R	ACH-001459	Colon/Colorectal Cancer	CCLE	VTPTPAGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SM3	Probable carboxypeptidase X1	DEG_SCF_FBW7_1	97:104	VTPTPAGT	FBXW7	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons