DegronMD

Uniprot ID: P08727

Source protein: Keratin, type I cytoskeletal 19

Source gene: KRT19

Class: DEG_APCC_DBOX_1

Location: 299:307

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6901

ASA_SCORE: 94.2556

COIL: 0.0251

CONS_SCORE: 0.9336

DSS_SCORE: 0.3127

HELIX: 0.9759

FCONS_SCORE: 1.0452

RIG_SCORE: 0.8009

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D298E	TCGA-27-1833	GBM	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.3056
p.D298E	DO12976	GBM	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.3056
p.R301H	TCGA-AX-A0J1	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	TCGA-B5-A11E	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	TCGA-R5-A7ZI	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	DO222342	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	DO41644	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	DO41199	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	ACH-001610	Brain Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.G305D	TCGA-VQ-A8P2	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.6087
p.G305D	DO51761	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.6087
p.T297I	TCGA-YU-A90W	TGCT	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.2778
p.E307Q	TCGA-ZF-A9R2	BLCA	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.5633
p.E307Q	DO219058	BLCA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.5633
p.Q311K	DO229034	LICA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.2222
p.L303F	DO220913	MELA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.6981
p.E307D	SIDM00630	Breast Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.5647
p.E307D	ACH-000876	Breast Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.5647
p.M316R	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.0833
p.M316R	SIDM00511	Small Cell Lung Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.0833
p.M316R	SIDM01624	Bladder Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.0833
p.M316R	SIDM01529	Bladder Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.0833
p.M316R	SIDM01760	Rhabdomyosarcoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.0833
p.R300W	SIDM00185	Melanoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.8634
p.R300W	SIDM01650	Non-Cancerous	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.8634
p.R300W	ACH-002354	Non-Cancerous	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.8634
p.E295K	SIDM00889	Cervical Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.2222
p.E295K	ACH-001333	Cervical Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.2222
p.E295K	C-33-A	cervix	COSMIC	LRRTLQGLE	DEG_APCC_DBOX_1	0.2222
p.T302S	SIDM00244	Neuroblastoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7116
p.T302S	ACH-002083	Neuroblastoma	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.7116
p.T302S	NB69	autonomic_ganglia	COSMIC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7116
p.Q304K	ACH-000740	Head and Neck Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRTLQGLE

Degron related mutations and impact score

Drug responses associated with KRT19 mutations

All proteins holding degron of LRRTLQGLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08727	Keratin, type I cytoskeletal 19	DEG_APCC_DBOX_1	299:307	LRRTLQGLE	APC,CDC20,FZR1	0.6901	More...