DegronMD

Uniprot ID: P08727

Source protein: Keratin, type I cytoskeletal 19

Source gene: KRT19

Class: DEG_APCC_DBOX_1

Location: 299:307

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6901

ASA_SCORE: 94.2556

COIL: 0.0251

CONS_SCORE: 0.9336

DSS_SCORE: 0.3127

HELIX: 0.9759

FCONS_SCORE: 1.0452

RIG_SCORE: 0.8009

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R300W	SIDM00185	Melanoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.8634
p.R300W	SIDM01650	Non-Cancerous	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.8634
p.R300W	ACH-002354	Non-Cancerous	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.8634
p.R301H	TCGA-AX-A0J1	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	TCGA-B5-A11E	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	TCGA-R5-A7ZI	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	DO222342	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	DO41644	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	DO41199	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.R301H	ACH-001610	Brain Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.7133
p.T302S	SIDM00244	Neuroblastoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7116
p.T302S	ACH-002083	Neuroblastoma	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.7116
p.T302S	NB69	autonomic_ganglia	COSMIC	LRRTLQGLE	DEG_APCC_DBOX_1	0.7116
p.L303F	DO220913	MELA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.6981
p.G305D	TCGA-VQ-A8P2	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.6087
p.G305D	DO51761	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.6087
p.Q304K	ACH-000740	Head and Neck Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.5833
p.E307D	SIDM00630	Breast Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	0.5647
p.E307D	ACH-000876	Breast Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	0.5647
p.E307Q	TCGA-ZF-A9R2	BLCA	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.5633
p.E307Q	DO219058	BLCA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.5633
p.D298E	TCGA-27-1833	GBM	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.3056
p.D298E	DO12976	GBM	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.3056
p.T297I	TCGA-YU-A90W	TGCT	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	0.2778
p.Q311K	DO229034	LICA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	0.2222

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Drug responses associated with KRT19 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRRTLQGLE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08727	Keratin, type I cytoskeletal 19	DEG_APCC_DBOX_1	299:307	LRRTLQGLE	APC,CDC20,FZR1	0.6901	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRTLQGLE

Degron related mutations and impact score

Drug responses associated with KRT19 mutations

All proteins holding degron of LRRTLQGLE