DegronMD - P08727(KRT19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D298E	TCGA-27-1833	GBM	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.D298E	DO12976	GBM	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.Y61C	TCGA-91-6829	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.6667
p.Y61C	DO23564	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.6667
p.A50S	TCGA-95-7043	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A50S	DO24739	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.G59E	TCGA-AP-A1DK	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.G59E	DO42033	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.R301H	TCGA-AX-A0J1	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	TCGA-B5-A11E	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	TCGA-R5-A7ZI	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	DO222342	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	DO41644	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	DO41199	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	ACH-001610	Brain Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.A60S	TCGA-CM-4743	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A60S	DO8103	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.S57T	TCGA-LL-A8F5	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.6005
p.S57T	DO50068	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.6005
p.G305D	TCGA-VQ-A8P2	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.6087
p.G305D	DO51761	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.6087
p.T297I	TCGA-YU-A90W	TGCT	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.2778
p.E307Q	TCGA-ZF-A9R2	BLCA	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.5633
p.E307Q	DO219058	BLCA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.5633
p.S48F	DO224722	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.6389
p.A60G	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A60G	DO229013	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A60G	DO229016	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A60G	DO229003	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A60G	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R51H	DO228239	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.R51H	SIDM01617	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.R51H	ACH-000994	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.Q311K	DO229034	LICA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.2222
p.L303F	DO220913	MELA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.6981
p.R51C	DO233299	NACA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.V45I	DO229234	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111
p.S54F	DO229250	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.6871
p.E307D	SIDM00630	Breast Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.5647
p.E307D	ACH-000876	Breast Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.5647
p.M316R	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0833
p.M316R	SIDM00511	Small Cell Lung Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0833
p.M316R	SIDM01624	Bladder Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0833
p.M316R	SIDM01529	Bladder Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0833
p.M316R	SIDM01760	Rhabdomyosarcoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0833
p.R300W	SIDM00185	Melanoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.8634
p.R300W	SIDM01650	Non-Cancerous	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.8634
p.R300W	ACH-002354	Non-Cancerous	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.8634
p.E295K	SIDM00889	Cervical Carcinoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.2222
p.E295K	ACH-001333	Cervical Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.2222
p.E295K	C-33-A	cervix	COSMIC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.2222
p.T302S	SIDM00244	Neuroblastoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7116
p.T302S	ACH-002083	Neuroblastoma	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7116
p.T302S	NB69	autonomic ganglia	COSMIC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7116
p.Q304K	ACH-000740	Head and Neck Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT19

UniProt ID: P08727

Entrez ID: 3880

Protein name: Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT19 in