DegronMD - P08727(KRT19)

FUNCTION: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.

GO - Biological processes (BP): cell differentiation involved in embryonic placenta development [GO:0060706]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; Notch signaling pathway [GO:0007219]; response to estrogen [GO:0043627]; sarcomere organization [GO:0045214]

GO - Molecular function (MF): structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]

GO - Cellular component (CC): apicolateral plasma membrane [GO:0016327]; cell periphery [GO:0071944]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; terminal web [GO:1990357]; Z... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R300W	SIDM00185	Melanoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.8634
p.R300W	SIDM01650	Non-Cancerous	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.8634
p.R300W	ACH-002354	Non-Cancerous	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.8634
p.R301H	TCGA-AX-A0J1	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	TCGA-B5-A11E	UCEC	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	TCGA-R5-A7ZI	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	DO222342	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	DO41644	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	DO41199	UCEC	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.R301H	ACH-001610	Brain Cancer	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7133
p.T302S	SIDM00244	Neuroblastoma	GDSC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7116
p.T302S	ACH-002083	Neuroblastoma	CCLE	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7116
p.T302S	NB69	autonomic ganglia	COSMIC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7116
p.L303F	DO220913	MELA	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.6981
p.S54F	DO229250	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.6871
p.Y61C	TCGA-91-6829	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.6667
p.Y61C	DO23564	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.6667
p.S48F	DO224722	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	53:57	Mutation blocking phosphorylation signal	0.6389
p.G305D	TCGA-VQ-A8P2	STAD	TCGA	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.6087
p.G305D	DO51761	STAD	ICGC	LRRTLQGLE	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.6087

Showing 1 to 20 of 55 entries

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Kaplan plot for KRT19 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT19

UniProt ID: P08727

Entrez ID: 3880

Protein name: Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT19 in