Degron: VSSSS
56.4
0.8244
0.7756
0.2509
0.0574
1.1012
0.679
Degron related mutations and impact score
| Mutation | Sample | Cancer | Dataset | Degron | Degron class | Impact score |
| p.Y61C | TCGA-91-6829 | LUAD | TCGA | VSSSS | DEG_SPOP_SBC_1 | 0.6667 |
| p.Y61C | DO23564 | LUAD | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.6667 |
| p.A50S | TCGA-95-7043 | LUAD | TCGA | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.A50S | DO24739 | LUAD | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.G59E | TCGA-AP-A1DK | UCEC | TCGA | VSSSS | DEG_SPOP_SBC_1 | 0.2778 |
| p.G59E | DO42033 | UCEC | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.2778 |
| p.A60S | TCGA-CM-4743 | COAD | TCGA | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.A60S | DO8103 | COAD | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.S57T | TCGA-LL-A8F5 | BRCA | TCGA | VSSSS | DEG_SPOP_SBC_1 | 0.6005 |
| p.S57T | DO50068 | BRCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.6005 |
| p.S48F | DO224722 | BRCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.6389 |
| p.A60G | DO229010 | COCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.A60G | DO229013 | COCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.A60G | DO229016 | COCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.A60G | DO229003 | COCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.A60G | DO229005 | COCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.25 |
| p.R51H | DO228239 | LICA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.2778 |
| p.R51H | SIDM01617 | Endometrial Carcinoma | GDSC | VSSSS | DEG_SPOP_SBC_1 | 0.2778 |
| p.R51H | ACH-000994 | Endometrial/Uterine Cancer | CCLE | VSSSS | DEG_SPOP_SBC_1 | 0.2778 |
| p.R51C | DO233299 | NACA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.2778 |
| p.V45I | DO229234 | THCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.1111 |
| p.S54F | DO229250 | THCA | ICGC | VSSSS | DEG_SPOP_SBC_1 | 0.6871 |
Drug responses associated with KRT19 mutations
| Sample | Cancer | Mutation (In Degron?) | Dataset | Drug | IC50 |
All proteins holding degron of VSSSS
| Uniprot ID | Source protein | Degron class | Location | Hit | E3 ligase | Degron score | Detail |
| A6NKB5 | Pecanex-like protein 2 | DEG_SPOP_SBC_1 | 745:749 | VSSSS | SPOP | 0.8267 | More... |
| A8CG34 | Nuclear envelope pore membrane protein POM 121C | DEG_SPOP_SBC_1 | 820:824 | VSSSS | SPOP | 0.967 | More... |
| O15265 | Ataxin-7 | DEG_SPOP_SBC_1 | 646:650 | VSSSS | SPOP | 0.7785 | More... |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | DEG_SPOP_SBC_1 | 388:392 | VSSSS | SPOP | 0.9965 | More... |
| O60315 | Zinc finger E-box-binding homeobox 2 | DEG_SPOP_SBC_1 | 849:853 | VSSSS | SPOP | 0.9885 | More... |
| O60447 | Ecotropic viral integration site 5 protein homolog | DEG_SPOP_SBC_1 | 118:122 | VSSSS | SPOP | 0.9992 | More... |
| O75038 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 | DEG_SPOP_SBC_1 | 1143:1147 | VSSSS | SPOP | 0.984 | More... |
| O75928 | E3 SUMO-protein ligase PIAS2 | DEG_SPOP_SBC_1 | 595:599 | VSSSS | SPOP | 0.9481 | More... |
| O95197 | Reticulon-3 | DEG_SPOP_SBC_1 | 51:55 | VSSSS | SPOP | 0.5294 | More... |
| P08670 | Vimentin | DEG_SPOP_SBC_1 | 6:10 | VSSSS | SPOP | 0.9968 | More... |
| P08727 | Keratin, type I cytoskeletal 19 | DEG_SPOP_SBC_1 | 53:57 | VSSSS | SPOP | 0.8181 | More... |
| P20823 | Hepatocyte nuclear factor 1-alpha | DEG_SPOP_SBC_1 | 590:594 | VSSSS | SPOP | 0.9502 | More... |
| P28324 | ETS domain-containing protein Elk-4 | DEG_SPOP_SBC_1 | 113:117 | VSSSS | SPOP | 0.9903 | More... |
| P42694 | Probable helicase with zinc finger domain | DEG_SPOP_SBC_1 | 1737:1741 | VSSSS | SPOP | 0.9969 | More... |
| P49790 | Nuclear pore complex protein Nup153 | DEG_SPOP_SBC_1 | 907:911 | VSSSS | SPOP | 0.9975 | More... |
| P49790 | Nuclear pore complex protein Nup153 | DEG_SPOP_SBC_1 | 1365:1369 | VSSSS | SPOP | 0.9892 | More... |
| P49792 | E3 SUMO-protein ligase RanBP2 | DEG_SPOP_SBC_1 | 2238:2242 | VSSSS | SPOP | 0.9963 | More... |
| P53999 | Activated RNA polymerase II transcriptional coactivator p15 | DEG_SPOP_SBC_1 | 8:12 | VSSSS | SPOP | 0.9826 | More... |
| P56715 | Oxygen-regulated protein 1 | DEG_SPOP_SBC_1 | 1686:1690 | VSSSS | SPOP | 0.9538 | More... |
| Q01484 | Ankyrin-2 | DEG_SPOP_SBC_1 | 2660:2664 | VSSSS | SPOP | 0.9717 | More... |
| Q02505 | Mucin-3A | DEG_SPOP_SBC_1 | 474:478 | VSSSS | SPOP | 0.972 | More... |
| Q02505 | Mucin-3A | DEG_SPOP_SBC_1 | 1226:1230 | VSSSS | SPOP | 0.9333 | More... |
| Q06710 | Paired box protein Pax-8 | DEG_SPOP_SBC_1 | 314:318 | VSSSS | SPOP | 0.9913 | More... |
| Q10571 | Transcriptional activator MN1 | DEG_SPOP_SBC_1 | 1059:1063 | VSSSS | SPOP | 0.9938 | More... |
| Q13023 | A-kinase anchor protein 6 | DEG_SPOP_SBC_1 | 325:329 | VSSSS | SPOP | 0.9847 | More... |
| Q13641 | Trophoblast glycoprotein | DEG_SPOP_SBC_1 | 29:33 | VSSSS | SPOP | 0.7118 | More... |
| Q16836 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | DEG_SPOP_SBC_1 | 12:16 | VSSSS | SPOP | 0.5131 | More... |
| Q2V2M9 | FH1/FH2 domain-containing protein 3 | DEG_SPOP_SBC_1 | 630:634 | VSSSS | SPOP | 0.9871 | More... |
| Q496A3 | Spermatogenesis-associated serine-rich protein 1 | DEG_SPOP_SBC_1 | 70:74 | VSSSS | SPOP | 0.9801 | More... |
| Q4LE39 | AT-rich interactive domain-containing protein 4B | DEG_SPOP_SBC_1 | 1096:1100 | VSSSS | SPOP | 0.9544 | More... |
| Q68DC2 | Ankyrin repeat and SAM domain-containing protein 6 | DEG_SPOP_SBC_1 | 752:756 | VSSSS | SPOP | 0.9841 | More... |
| Q68DE3 | Basic helix-loop-helix domain-containing protein USF3 | DEG_SPOP_SBC_1 | 1277:1281 | VSSSS | SPOP | 0.9565 | More... |
| Q68DQ2 | Very large A-kinase anchor protein | DEG_SPOP_SBC_1 | 1060:1064 | VSSSS | SPOP | 0.9641 | More... |
| Q6PCD5 | E3 ubiquitin-protein ligase RFWD3 | DEG_SPOP_SBC_1 | 210:214 | VSSSS | SPOP | 0.6762 | More... |
| Q6ZRI0 | Otogelin | DEG_SPOP_SBC_1 | 61:65 | VSSSS | SPOP | 0.7564 | More... |
| Q76L83 | Putative Polycomb group protein ASXL2 | DEG_SPOP_SBC_1 | 135:139 | VSSSS | SPOP | 0.9764 | More... |
| Q7Z3B3 | KAT8 regulatory NSL complex subunit 1 | DEG_SPOP_SBC_1 | 580:584 | VSSSS | SPOP | 0.9616 | More... |
| Q7Z3E5 | LisH domain-containing protein ARMC9 | DEG_SPOP_SBC_1 | 707:711 | VSSSS | SPOP | 0.992 | More... |
| Q7Z460 | CLIP-associating protein 1 | DEG_SPOP_SBC_1 | 614:618 | VSSSS | SPOP | 0.9887 | More... |
| Q86YJ7 | Ankyrin repeat domain-containing protein 13B | DEG_SPOP_SBC_1 | 464:468 | VSSSS | SPOP | 0.9801 | More... |
| Q8IZP9 | Adhesion G-protein coupled receptor G2 | DEG_SPOP_SBC_1 | 924:928 | VSSSS | SPOP | 0.9158 | More... |
| Q8NDV7 | Trinucleotide repeat-containing gene 6A protein | DEG_SPOP_SBC_1 | 348:352 | VSSSS | SPOP | 0.9933 | More... |
| Q8NFM7 | Interleukin-17 receptor D | DEG_SPOP_SBC_1 | 696:700 | VSSSS | SPOP | 0.9954 | More... |
| Q8NFY4 | Semaphorin-6D | DEG_SPOP_SBC_1 | 592:596 | VSSSS | SPOP | 0.9857 | More... |
| Q8TEC5 | E3 ubiquitin-protein ligase SH3RF2 | DEG_SPOP_SBC_1 | 274:278 | VSSSS | SPOP | 0.9926 | More... |
| Q8TF01 | Arginine/serine-rich protein PNISR | DEG_SPOP_SBC_1 | 531:535 | VSSSS | SPOP | 0.99 | More... |
| Q8WXI7 | Mucin-16 | DEG_SPOP_SBC_1 | 9437:9441 | VSSSS | SPOP | 0.9436 | More... |
| Q96A56 | Tumor protein p53-inducible nuclear protein 1 | DEG_SPOP_SBC_1 | 13:17 | VSSSS | SPOP | 0.5189 | More... |
| Q96CN4 | EVI5-like protein | DEG_SPOP_SBC_1 | 70:74 | VSSSS | SPOP | 0.6625 | More... |
| Q96CN9 | GRIP and coiled-coil domain-containing protein 1 | DEG_SPOP_SBC_1 | 140:144 | VSSSS | SPOP | 0.8322 | More... |
| Q96HA1 | Nuclear envelope pore membrane protein POM 121 | DEG_SPOP_SBC_1 | 843:847 | VSSSS | SPOP | 0.9898 | More... |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | DEG_SPOP_SBC_1 | 1595:1599 | VSSSS | SPOP | 0.9925 | More... |
| Q96S65 | Cysteine/serine-rich nuclear protein 1 | DEG_SPOP_SBC_1 | 19:23 | VSSSS | SPOP | 0.9896 | More... |
| Q99700 | Ataxin-2 | DEG_SPOP_SBC_1 | 219:223 | VSSSS | SPOP | 0.5809 | More... |
| Q9C004 | Protein sprouty homolog 4 | DEG_SPOP_SBC_1 | 99:103 | VSSSS | SPOP | 0.9969 | More... |
| Q9C091 | GREB1-like protein | DEG_SPOP_SBC_1 | 1138:1142 | VSSSS | SPOP | 0.995 | More... |
| Q9C0D2 | Centrosomal protein of 295 kDa | DEG_SPOP_SBC_1 | 1097:1101 | VSSSS | SPOP | 0.9942 | More... |
| Q9H040 | DNA-dependent metalloprotease SPRTN | DEG_SPOP_SBC_1 | 364:368 | VSSSS | SPOP | 0.9992 | More... |
| Q9NRF2 | SH2B adapter protein 1 | DEG_SPOP_SBC_1 | 137:141 | VSSSS | SPOP | 0.9967 | More... |
| Q9P1Z0 | Zinc finger and BTB domain-containing protein 4 | DEG_SPOP_SBC_1 | 824:828 | VSSSS | SPOP | 0.9843 | More... |
| Q9P278 | Folliculin-interacting protein 2 | DEG_SPOP_SBC_1 | 98:102 | VSSSS | SPOP | 0.9898 | More... |
| Q9UHL9 | General transcription factor II-I repeat domain-containing protein 1 | DEG_SPOP_SBC_1 | 911:915 | VSSSS | SPOP | 0.9873 | More... |
| Q9UKV0 | Histone deacetylase 9 | DEG_SPOP_SBC_1 | 266:270 | VSSSS | SPOP | 0.9845 | More... |
| Q9UMR3 | T-box transcription factor TBX20 | DEG_SPOP_SBC_1 | 350:354 | VSSSS | SPOP | 0.981 | More... |
| Q9UPN6 | SR-related and CTD-associated factor 8 | DEG_SPOP_SBC_1 | 834:838 | VSSSS | SPOP | 0.931 | More... |
| Q9UPQ0 | LIM and calponin homology domains-containing protein 1 | DEG_SPOP_SBC_1 | 834:838 | VSSSS | SPOP | 0.9719 | More... |
| Q9Y2L5 | Trafficking protein particle complex subunit 8 | DEG_SPOP_SBC_1 | 1125:1129 | VSSSS | SPOP | 0.5281 | More... |
| Q9Y6V0 | Protein piccolo | DEG_SPOP_SBC_1 | 767:771 | VSSSS | SPOP | 0.9948 | More... |
| Q9Y6Y8 | SEC23-interacting protein | DEG_SPOP_SBC_1 | 86:90 | VSSSS | SPOP | 0.9889 | More... |
| O14513 | Nck-associated protein 5 | DEG_SPOP_SBC_1 | 1115:1119 | VSSSS | SPOP | 0.9844 | More... |
| Q13203 | Myosin-binding protein H | DEG_SPOP_SBC_1 | 82:86 | VSSSS | SPOP | 0.5759 | More... |
| Q5VTQ0 | Tetratricopeptide repeat protein 39B | DEG_SPOP_SBC_1 | 122:126 | VSSSS | SPOP | 0.7044 | More... |
| Q8N3X1 | Formin-binding protein 4 | DEG_SPOP_SBC_1 | 681:685 | VSSSS | SPOP | 0.8869 | More... |
| Q96GY0 | Zinc finger C2HC domain-containing protein 1A | DEG_SPOP_SBC_1 | 208:212 | VSSSS | SPOP | 0.9983 | More... |
| Q99666 | RANBP2-like and GRIP domain-containing protein 5/6 | DEG_SPOP_SBC_1 | 1262:1266 | VSSSS | SPOP | 0.9992 | More... |
| Q99742 | Neuronal PAS domain-containing protein 1 | DEG_SPOP_SBC_1 | 213:217 | VSSSS | SPOP | 0.8715 | More... |
| A6NKT7 | RanBP2-like and GRIP domain-containing protein 3 | DEG_SPOP_SBC_1 | 1263:1267 | VSSSS | SPOP | 0.9997 | More... |
| O14715 | RANBP2-like and GRIP domain-containing protein 8 | DEG_SPOP_SBC_1 | 1262:1266 | VSSSS | SPOP | 0.9995 | More... |
| P0DJD0 | RANBP2-like and GRIP domain-containing protein 1 | DEG_SPOP_SBC_1 | 1247:1251 | VSSSS | SPOP | 0.999 | More... |
| P0DJD1 | RANBP2-like and GRIP domain-containing protein 2 | DEG_SPOP_SBC_1 | 1255:1259 | VSSSS | SPOP | 0.9939 | More... |
| Q32P51 | Heterogeneous nuclear ribonucleoprotein A1-like 2 | DEG_SPOP_SBC_1 | 307:311 | VSSSS | SPOP | 0.9897 | More... |
| Q5BJE1 | Coiled-coil domain-containing protein 178 | DEG_SPOP_SBC_1 | 7:11 | VSSSS | SPOP | 0.9195 | More... |
| Q6ZU65 | Ubinuclein-2 | DEG_SPOP_SBC_1 | 897:901 | VSSSS | SPOP | 0.9592 | More... |
| Q6ZWB6 | BTB/POZ domain-containing protein KCTD8 | DEG_SPOP_SBC_1 | 20:24 | VSSSS | SPOP | 0.9622 | More... |
| Q7Z3J3 | RanBP2-like and GRIP domain-containing protein 4 | DEG_SPOP_SBC_1 | 1263:1267 | VSSSS | SPOP | 0.995 | More... |
| Q96N46 | Tetratricopeptide repeat protein 14 | DEG_SPOP_SBC_1 | 488:492 | VSSSS | SPOP | 0.9738 | More... |
| Q9P281 | BAH and coiled-coil domain-containing protein 1 | DEG_SPOP_SBC_1 | 2347:2351 | VSSSS | SPOP | 0.7666 | More... |
| Q9P2B7 | Cilia- and flagella-associated protein 97 | DEG_SPOP_SBC_1 | 169:173 | VSSSS | SPOP | 0.9947 | More... |
| A4D263 | Spermatogenesis-associated protein 48 | DEG_SPOP_SBC_1 | 313:317 | VSSSS | SPOP | 0.5985 | More... |
| A6NDY2 | Putative protein FAM90A10 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.8843 | More... |
| A6NE21 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9592 | More... | |
| A6NEW6 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.8989 | More... | |
| A6NF01 | Putative nuclear envelope pore membrane protein POM 121B | DEG_SPOP_SBC_1 | 427:431 | VSSSS | SPOP | 0.986 | More... |
| A6NIJ5 | Putative protein FAM90A20P | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9636 | More... |
| A6NJQ4 | Putative protein FAM90A8 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9647 | More... |
| A6NKC0 | Putative protein FAM90A7 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9592 | More... |
| A6NNJ1 | Putative protein FAM90A9 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.8064 | More... |
| A8MWA6 | Putative protein FAM90A22 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9841 | More... |
| A8MX19 | Putative protein FAM90A12P | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.8989 | More... |
| A8MXJ8 | Putative protein FAM90A5P | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.8961 | More... |
| A8MXZ1 | Putative protein FAM90A23 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9647 | More... |
| D6RGX4 | Putative protein FAM90A26 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.902 | More... |
| P0C7V4 | Putative protein FAM90A15P | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9636 | More... |
| P0C7W8 | Putative protein FAM90A13P | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9636 | More... |
| P0C7W9 | Putative protein FAM90A14 | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.9636 | More... |
| P0C7X0 | Putative protein FAM90A24P | DEG_SPOP_SBC_1 | 452:456 | VSSSS | SPOP | 0.8989 | More... |
| Q5HYC2 | Uncharacterized protein KIAA2026 | DEG_SPOP_SBC_1 | 1306:1310 | VSSSS | SPOP | 0.995 | More... |
| Q658T7 | Putative protein FAM90A2P | DEG_SPOP_SBC_1 | 451:455 | VSSSS | SPOP | 0.9777 | More... |
| Q6ZU69 | Protein FAM205A | DEG_SPOP_SBC_1 | 627:631 | VSSSS | SPOP | 0.6008 | More... |
| Q96GX8 | Uncharacterized protein C16orf74 | DEG_SPOP_SBC_1 | 15:19 | VSSSS | SPOP | 0.8333 | More... |