DegronMD - Q8TEC5(SH3RF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A490S	TCGA-24-2262	OV	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7588
p.A490S	DO28843	OV	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7588
p.V120A	TCGA-2W-A8YY	CESC	TCGA	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6936
p.V120A	DO223732	CESC	ICGC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6936
p.N270K	TCGA-44-8119	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.N270K	DO24399	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.A111T	TCGA-B7-5816	STAD	TCGA	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0833
p.A111T	DO38599	STAD	ICGC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0833
p.M124I	TCGA-D3-A5GO	SKCM	TCGA	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6507
p.M124I	DO47419	SKCM	ICGC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6507
p.R480C	TCGA-D7-8575	STAD	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480C	DO228124	EOPC	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480C	DO233245	GACA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480C	DO47755	STAD	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480C	SIDM00853	Other Sarcomas	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480C	ACH-000835	Sarcoma	CCLE	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480C	GCT	soft tissue	COSMIC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.H123Y	TCGA-DA-A95Y	SKCM	TCGA	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6118
p.H123Y	DO218863	SKCA	ICGC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6118
p.H123Y	DO223908	SKCM	ICGC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6118
p.L271P	TCGA-DF-A2KN	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.25
p.L271P	DO223282	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.25
p.L273M	TCGA-EE-A29E	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.3056
p.L273M	DO37831	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.3056
p.P494L	TCGA-EE-A2MT	SKCM	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7582
p.P494L	DO220906	MELA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7582
p.P494L	DO38051	SKCM	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7582
p.P481L	TCGA-EE-A3JI	SKCM	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1667
p.P481L	DO222837	MELA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1667
p.P481L	DO47268	SKCM	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1667
p.R267H	TCGA-EY-A215	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R267H	DO42665	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R480H	TCGA-KQ-A41R	BLCA	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480H	DO223592	BLCA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480H	SIDM00238	Ovarian Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480H	SIDM00279	Gastric Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480H	OVK-18	ovary	COSMIC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.R480H	ECC12	stomach	COSMIC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1389
p.L271M	TCGA-ND-A4WC	UCS	TCGA	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.25
p.R477W	TCGA-VQ-A8P2	STAD	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.R477W	DO51761	STAD	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.G505R	TCGA-YG-AA3O	SKCM	TCGA	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.G505R	DO51299	SKCM	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.R477Q	DO222794	COCA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.R477Q	DO220891	MELA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.R477Q	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.R477Q	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0556
p.R267C	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R267C	DO229013	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R267C	DO229003	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R267C	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R267C	DO230965	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.V485I	DO233653	GACA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.2778
p.V485I	SIDM01113	Other Sarcomas	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.2778
p.V485I	SK-UT-1	soft tissue	COSMIC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.2778
p.V492F	DO229008	LICA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7068
p.T282M	DO50813	LIRI	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.G288S	DO222632	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.0556
p.P494T	DO27907	ORCA	ICGC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7031
p.P494T	SIDM01119	Other Solid Cancers	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7031
p.P494T	ACH-000775	Lung Cancer	CCLE	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7031
p.P494T	NCI-H727	lung	COSMIC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation altering degron motif	0.7031
p.S266Y	DO46400	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1111
p.S266Y	DO51493	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1111
p.R286C	DO36221	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1111
p.S276L	SIDM00401	Melanoma	GDSC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S276L	ACH-000614	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S276L	ACH-002461	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S276L	RVH-421	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.K131N	SIDM00889	Cervical Carcinoma	GDSC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation substituting flanking lysine	0.2778
p.K131N	ACH-001333	Cervical Cancer	CCLE	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation substituting flanking lysine	0.2778
p.K131N	C-33-A	cervix	COSMIC	VRIHMD	LIG_APCC_ABBA_1	120:125	Mutation substituting flanking lysine	0.2778
p.L504S	SIDM01045	Endometrial Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0833
p.L504S	ACH-000978	Endometrial/Uterine Cancer	CCLE	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0833
p.L504S	EN	endometrium	COSMIC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.0833
p.G500V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1944
p.G500V	ACH-000553	Lung Cancer	CCLE	VPTAIVNPV	DEG_SIAH_1	487:495	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3RF2

UniProt ID: Q8TEC5

Entrez ID: 153769

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3RF2 in