DegronMD

Uniprot ID: Q8TEC5

Source protein: E3 ubiquitin-protein ligase SH3RF2

Source gene: SH3RF2

Class: DEG_SIAH_1

Location: 487:495

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9901

ASA_SCORE: 80.5667

COIL: 0.8856

CONS_SCORE: 0.636

DSS_SCORE: 0.4458

HELIX: 0.02

FCONS_SCORE: 1.1275

RIG_SCORE: 0.7801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A490S	TCGA-24-2262	OV	TCGA	VPTAIVNPV	DEG_SIAH_1	0.7588
p.A490S	DO28843	OV	ICGC	VPTAIVNPV	DEG_SIAH_1	0.7588
p.R480C	TCGA-D7-8575	STAD	TCGA	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480C	DO228124	EOPC	ICGC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480C	DO233245	GACA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480C	DO47755	STAD	ICGC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480C	SIDM00853	Other Sarcomas	GDSC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480C	ACH-000835	Sarcoma	CCLE	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480C	GCT	soft_tissue	COSMIC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.P494L	TCGA-EE-A2MT	SKCM	TCGA	VPTAIVNPV	DEG_SIAH_1	0.7582
p.P494L	DO220906	MELA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.7582
p.P494L	DO38051	SKCM	ICGC	VPTAIVNPV	DEG_SIAH_1	0.7582
p.P481L	TCGA-EE-A3JI	SKCM	TCGA	VPTAIVNPV	DEG_SIAH_1	0.1667
p.P481L	DO222837	MELA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.1667
p.P481L	DO47268	SKCM	ICGC	VPTAIVNPV	DEG_SIAH_1	0.1667
p.R480H	TCGA-KQ-A41R	BLCA	TCGA	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480H	DO223592	BLCA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480H	SIDM00238	Ovarian Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480H	SIDM00279	Gastric Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480H	OVK-18	ovary	COSMIC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R480H	ECC12	stomach	COSMIC	VPTAIVNPV	DEG_SIAH_1	0.1389
p.R477W	TCGA-VQ-A8P2	STAD	TCGA	VPTAIVNPV	DEG_SIAH_1	0.0556
p.R477W	DO51761	STAD	ICGC	VPTAIVNPV	DEG_SIAH_1	0.0556
p.G505R	TCGA-YG-AA3O	SKCM	TCGA	VPTAIVNPV	DEG_SIAH_1	0.0556
p.G505R	DO51299	SKCM	ICGC	VPTAIVNPV	DEG_SIAH_1	0.0556
p.R477Q	DO222794	COCA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.0556
p.R477Q	DO220891	MELA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.0556
p.R477Q	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	0.0556
p.R477Q	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	0.0556
p.V485I	DO233653	GACA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.2778
p.V485I	SIDM01113	Other Sarcomas	GDSC	VPTAIVNPV	DEG_SIAH_1	0.2778
p.V485I	SK-UT-1	soft_tissue	COSMIC	VPTAIVNPV	DEG_SIAH_1	0.2778
p.V492F	DO229008	LICA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.7068
p.P494T	DO27907	ORCA	ICGC	VPTAIVNPV	DEG_SIAH_1	0.7031
p.P494T	SIDM01119	Other Solid Cancers	GDSC	VPTAIVNPV	DEG_SIAH_1	0.7031
p.P494T	ACH-000775	Lung Cancer	CCLE	VPTAIVNPV	DEG_SIAH_1	0.7031
p.P494T	NCI-H727	lung	COSMIC	VPTAIVNPV	DEG_SIAH_1	0.7031
p.L504S	SIDM01045	Endometrial Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	0.0833
p.L504S	ACH-000978	Endometrial/Uterine Cancer	CCLE	VPTAIVNPV	DEG_SIAH_1	0.0833
p.L504S	EN	endometrium	COSMIC	VPTAIVNPV	DEG_SIAH_1	0.0833
p.G500V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPTAIVNPV	DEG_SIAH_1	0.1944
p.G500V	ACH-000553	Lung Cancer	CCLE	VPTAIVNPV	DEG_SIAH_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTAIVNPV

Degron related mutations and impact score

Drug responses associated with SH3RF2 mutations

All proteins holding degron of VPTAIVNPV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEC5	E3 ubiquitin-protein ligase SH3RF2	DEG_SIAH_1	487:495	VPTAIVNPV	SIAH1,SIAH2,SIAH3	0.9901	More...