DegronMD

Uniprot ID: Q8TEC5

Source protein: E3 ubiquitin-protein ligase SH3RF2

Source gene: SH3RF2

Class: LIG_APCC_ABBA_1

Location: 120:125

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8797

ASA_SCORE: 101.1167

COIL: 0.8253

CONS_SCORE: 0.6155

DSS_SCORE: 0.3755

HELIX: 0.078

FCONS_SCORE: 0.9324

RIG_SCORE: 0.7652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V120A	TCGA-2W-A8YY	CESC	TCGA	VRIHMD	LIG_APCC_ABBA_1	0.6936
p.V120A	DO223732	CESC	ICGC	VRIHMD	LIG_APCC_ABBA_1	0.6936
p.A111T	TCGA-B7-5816	STAD	TCGA	VRIHMD	LIG_APCC_ABBA_1	0.0833
p.A111T	DO38599	STAD	ICGC	VRIHMD	LIG_APCC_ABBA_1	0.0833
p.M124I	TCGA-D3-A5GO	SKCM	TCGA	VRIHMD	LIG_APCC_ABBA_1	0.6507
p.M124I	DO47419	SKCM	ICGC	VRIHMD	LIG_APCC_ABBA_1	0.6507
p.H123Y	TCGA-DA-A95Y	SKCM	TCGA	VRIHMD	LIG_APCC_ABBA_1	0.6118
p.H123Y	DO218863	SKCA	ICGC	VRIHMD	LIG_APCC_ABBA_1	0.6118
p.H123Y	DO223908	SKCM	ICGC	VRIHMD	LIG_APCC_ABBA_1	0.6118
p.K131N	SIDM00889	Cervical Carcinoma	GDSC	VRIHMD	LIG_APCC_ABBA_1	0.2778
p.K131N	ACH-001333	Cervical Cancer	CCLE	VRIHMD	LIG_APCC_ABBA_1	0.2778
p.K131N	C-33-A	cervix	COSMIC	VRIHMD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEC5	E3 ubiquitin-protein ligase SH3RF2	LIG_APCC_ABBA_1	120:125	VRIHMD	APC,CDC20,FZR1	0.8797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons