DegronMD - Q06710(PAX8)

GO - Biological processes (BP): anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to gonadotropin stimulus [GO:0071371]; central nervous system development [GO:0007417]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesonephros development [GO:0001823]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric nephron tubule formation [GO:0072289]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; otic vesicle development [GO:0071599]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; regulation of apoptotic process [GO:0042981]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of thyroid-stimulating hormone secretion [GO:2000612]; regulation of transcription by RNA polymerase II [GO:0006357]; sulfur compound metabolic process [GO:0006790]; thyroid gland development [GO:0030878]; transcription, DNA-templated [GO:0006351]; urogenital system development [GO:0001655]; ventricular septum development [GO:0003281] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P161R	TCGA-25-2393	OV	TCGA	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.2222
p.P161R	DO32153	OV	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.2222
p.P155H	TCGA-2Z-A9JG	KIRP	TCGA	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.P155H	DO219667	KIRP	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.I307T	TCGA-60-2724	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.I307T	DO26540	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.A164D	TCGA-66-2785	LUSC	TCGA	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.3056
p.A164D	DO26520	LUSC	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.3056
p.Y180H	TCGA-AA-3815	COAD	TCGA	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.Y180H	DO9924	COAD	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.R287H	TCGA-AU-6004	COAD	TCGA	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.R287H	DO7780	COAD	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.R287H	ACH-001688	Kidney Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.N282I	TCGA-DK-A6AW	BLCA	TCGA	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.6169
p.N282I	DO48566	BLCA	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.6169
p.A306T	TCGA-DU-6392	LGG	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1111
p.A306T	DO22237	LGG	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1111
p.A306T	DO51107	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1111
p.G274R	TCGA-EB-A44P	SKCM	TCGA	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.G274R	DO47525	SKCM	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.P321L	TCGA-EB-A6QY	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321L	TCGA-EE-A2GI	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321L	DO37410	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321L	DO48702	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321L	ACH-002396	Bone Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321L	Sarc9371	bone	COSMIC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321S	TCGA-EB-A6QY	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321S	DO48702	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321S	ACH-002396	Bone Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P321S	Sarc9371	bone	COSMIC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.S322F	TCGA-EE-A182	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.S322F	TCGA-EE-A2MM	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.S322F	DO222678	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.S322F	DO37814	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.S322F	DO37770	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.A328T	TCGA-FI-A2D5	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.A328T	DO41331	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.R287C	TCGA-FI-A2D5	UCEC	TCGA	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.R287C	DO41331	UCEC	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.R287C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.R287C	ACH-001127	Leukemia	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.R287C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2222
p.P155S	TCGA-FR-A726	SKCM	TCGA	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.P155S	DO48665	SKCM	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.P161S	TCGA-FW-A3R5	SKCM	TCGA	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.2222
p.P161S	DO37406	SKCM	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.2222
p.C325S	DO474	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.S309L	DO13863	GBM	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.S309L	MC116	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.P315H	DO50458	KIRC	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7694
p.S313Y	DO228900	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.S315Y	DO229019	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6009
p.D272E	DO229022	LICA	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1667
p.T283K	DO229041	LICA	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.7306
p.A276D	DO229041	LICA	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2778
p.M317L	DO45318	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.711
p.P323R	DO26532	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.P321F	DO222363	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P304S	DO222542	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.P167S	DO222880	MELA	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation altering degron motif	0.6752
p.P324T	DO32267	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.A310V	DO34208	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.A310V	DO232761	PBCA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.A164V	DO33552	PACA	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.3056
p.D174N	DO232761	PBCA	ICGC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.2222
p.T311S	DO232445	PBCA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.E310K	DO219878	SKCA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.G327S	DO229229	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.A276S	DO229221	THCA	ICGC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.2778
p.S307I	DO42472	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.V314L	SIDM00845	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6765
p.V314L	SIDM00461	Acute Myeloid Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6765
p.V314L	ACH-000992	Head and Neck Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6765
p.T283S	SIDM00465	Ovarian Carcinoma	GDSC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.6005
p.T283S	ACH-002183	Ovarian Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.6005
p.T283S	OVMIU	ovary	COSMIC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.6005
p.D273N	SIDM01186	Breast Carcinoma	GDSC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1944
p.D273N	SIDM00230	Small Cell Lung Carcinoma	GDSC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1944
p.D273N	ACH-000554	Breast Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1944
p.D273N	ACH-002145	Lung Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1944
p.D273N	IST-SL2	lung	COSMIC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1944
p.D273N	UACC-893	breast	COSMIC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1944
p.Y180C	SIDM01608	Endometrial Carcinoma	GDSC	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.Y180C	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTPPES	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.0556
p.S290W	ACH-000652	Pancreatic Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1389
p.L278M	ACH-001719	Ovarian Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.5999
p.P272R	C-33-A	cervix	COSMIC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation rewiring degron network	0.1667
p.A281E	NB7	autonomic ganglia	COSMIC	LTPSNT	DEG_SCF_FBW7_1	278:283	Mutation altering degron motif	0.7701
p.P320S	VMRC-LCD	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.P306R	C-33-A	cervix	COSMIC	VSSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1111

Kaplan plot for PAX8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAX8

UniProt ID: Q06710

Entrez ID: 7849

Protein name: Paired box protein Pax-8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAX8 in