DegronMD

Uniprot ID: Q06710

Source protein: Paired box protein Pax-8

Source gene: PAX8

Class: DEG_SCF_FBW7_1

Location: 278:283

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 73.6167

COIL: 0.927

CONS_SCORE: 0.6586

DSS_SCORE: 0.5947

HELIX: 0.0352

FCONS_SCORE: 1.0761

RIG_SCORE: 0.6922

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R287H	TCGA-AU-6004	COAD	TCGA	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287H	DO7780	COAD	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287H	ACH-001688	Kidney Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.N282I	TCGA-DK-A6AW	BLCA	TCGA	LTPSNT	DEG_SCF_FBW7_1	0.6169
p.N282I	DO48566	BLCA	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.6169
p.G274R	TCGA-EB-A44P	SKCM	TCGA	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.G274R	DO47525	SKCM	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287C	TCGA-FI-A2D5	UCEC	TCGA	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287C	DO41331	UCEC	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287C	ACH-001127	Leukemia	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.R287C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSNT	DEG_SCF_FBW7_1	0.2222
p.D272E	DO229022	LICA	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.1667
p.T283K	DO229041	LICA	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.7306
p.A276D	DO229041	LICA	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.2778
p.A276S	DO229221	THCA	ICGC	LTPSNT	DEG_SCF_FBW7_1	0.2778
p.T283S	SIDM00465	Ovarian Carcinoma	GDSC	LTPSNT	DEG_SCF_FBW7_1	0.6005
p.T283S	ACH-002183	Ovarian Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.6005
p.T283S	OVMIU	ovary	COSMIC	LTPSNT	DEG_SCF_FBW7_1	0.6005
p.D273N	SIDM01186	Breast Carcinoma	GDSC	LTPSNT	DEG_SCF_FBW7_1	0.1944
p.D273N	SIDM00230	Small Cell Lung Carcinoma	GDSC	LTPSNT	DEG_SCF_FBW7_1	0.1944
p.D273N	ACH-000554	Breast Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.1944
p.D273N	ACH-002145	Lung Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.1944
p.D273N	IST-SL2	lung	COSMIC	LTPSNT	DEG_SCF_FBW7_1	0.1944
p.D273N	UACC-893	breast	COSMIC	LTPSNT	DEG_SCF_FBW7_1	0.1944
p.S290W	ACH-000652	Pancreatic Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.1389
p.L278M	ACH-001719	Ovarian Cancer	CCLE	LTPSNT	DEG_SCF_FBW7_1	0.5999
p.P272R	C-33-A	cervix	COSMIC	LTPSNT	DEG_SCF_FBW7_1	0.1667
p.A281E	NB7	autonomic_ganglia	COSMIC	LTPSNT	DEG_SCF_FBW7_1	0.7701

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPSNT

Degron related mutations and impact score

Drug responses associated with PAX8 mutations

All proteins holding degron of LTPSNT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06710	Paired box protein Pax-8	DEG_SCF_FBW7_1	278:283	LTPSNT	FBXW7	0.9993	More...