DegronMD

Uniprot ID: Q06710

Source protein: Paired box protein Pax-8

Source gene: PAX8

Class: DEG_SPOP_SBC_1

Location: 314:318

E3 ligase: SPOP

DEGRON score: 0.9913

ASA_SCORE: 77.26

COIL: 0.9418

CONS_SCORE: 0.6462

DSS_SCORE: 0.5716

HELIX: 0.026

FCONS_SCORE: 1.0207

RIG_SCORE: 0.5957

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P315H	DO50458	KIRC	ICGC	VSSSS	DEG_SPOP_SBC_1	0.7694
p.M317L	DO45318	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	0.711
p.V314L	SIDM00845	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	0.6765
p.V314L	SIDM00461	Acute Myeloid Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	0.6765
p.V314L	ACH-000992	Head and Neck Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	0.6765
p.S315Y	DO229019	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.6009
p.S313Y	DO228900	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.3056
p.P320S	VMRC-LCD	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.2778
p.P321L	TCGA-EB-A6QY	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321L	TCGA-EE-A2GI	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321L	DO37410	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321L	DO48702	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321L	ACH-002396	Bone Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321L	Sarc9371	bone	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321S	TCGA-EB-A6QY	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321S	DO48702	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321S	ACH-002396	Bone Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321S	Sarc9371	bone	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.25
p.P321F	DO222363	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.25
p.T311S	DO232445	PBCA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.25
p.S322F	TCGA-EE-A182	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.2222
p.S322F	TCGA-EE-A2MM	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.2222
p.S322F	DO222678	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.2222
p.S322F	DO37814	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.2222
p.S322F	DO37770	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.2222

Showing 1 to 25 of 44 entries

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Drug responses associated with PAX8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VSSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NE21		DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9592	More...
A6NEW6		DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8989	More...
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1143:1147	VSSSS	SPOP	0.984	More...
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	388:392	VSSSS	SPOP	0.9965	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	325:329	VSSSS	SPOP	0.9847	More...
P53999	Activated RNA polymerase II transcriptional coactivator p15	DEG_SPOP_SBC_1	8:12	VSSSS	SPOP	0.9826	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	924:928	VSSSS	SPOP	0.9158	More...
Q68DC2	Ankyrin repeat and SAM domain-containing protein 6	DEG_SPOP_SBC_1	752:756	VSSSS	SPOP	0.9841	More...
Q86YJ7	Ankyrin repeat domain-containing protein 13B	DEG_SPOP_SBC_1	464:468	VSSSS	SPOP	0.9801	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2660:2664	VSSSS	SPOP	0.9717	More...
Q8TF01	Arginine/serine-rich protein PNISR	DEG_SPOP_SBC_1	531:535	VSSSS	SPOP	0.99	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1096:1100	VSSSS	SPOP	0.9544	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	219:223	VSSSS	SPOP	0.5809	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	646:650	VSSSS	SPOP	0.7785	More...
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_SPOP_SBC_1	1595:1599	VSSSS	SPOP	0.9925	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	2347:2351	VSSSS	SPOP	0.7666	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1277:1281	VSSSS	SPOP	0.9565	More...
Q6ZWB6	BTB/POZ domain-containing protein KCTD8	DEG_SPOP_SBC_1	20:24	VSSSS	SPOP	0.9622	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1097:1101	VSSSS	SPOP	0.9942	More...
Q9P2B7	Cilia- and flagella-associated protein 97	DEG_SPOP_SBC_1	169:173	VSSSS	SPOP	0.9947	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	614:618	VSSSS	SPOP	0.9887	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_SPOP_SBC_1	7:11	VSSSS	SPOP	0.9195	More...
Q96S65	Cysteine/serine-rich nuclear protein 1	DEG_SPOP_SBC_1	19:23	VSSSS	SPOP	0.9896	More...
Q9H040	DNA-dependent metalloprotease SPRTN	DEG_SPOP_SBC_1	364:368	VSSSS	SPOP	0.9992	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	595:599	VSSSS	SPOP	0.9481	More...

Showing 1 to 25 of 110 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSSS

Degron related mutations and impact score

Drug responses associated with PAX8 mutations

All proteins holding degron of VSSSS