DegronMD

Uniprot ID: Q9UKV0

Source protein: Histone deacetylase 9

Source gene: HDAC9

Class: DEG_SPOP_SBC_1

Location: 266:270

E3 ligase: SPOP

DEGRON score: 0.9845

ASA_SCORE: 97.28

COIL: 0.9566

CONS_SCORE: 0.3893

DSS_SCORE: 0.6243

HELIX: 0.0352

FCONS_SCORE: 1.0974

RIG_SCORE: 0.5337

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E263G	TCGA-17-Z031	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	0.25
p.G277V	TCGA-34-5240	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	0.1389
p.S256L	TCGA-EB-A41A	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.1667
p.R260Q	TCGA-EE-A3JD	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	0.1667
p.S280L	TCGA-EK-A2PG	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	0.0556
p.S267F	TCGA-GS-A9TZ	DLBC	TCGA	VSSSS	DEG_SPOP_SBC_1	0.6871
p.R280H	DO234239	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	0.0556
p.R280H	DO41020	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	0.0556
p.R280H	MDST8	large_intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.0556
p.L266F	DO233130	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.6981
p.V276D	DO44423	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	0.1667
p.M275I	DO27326	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	0.1944
p.N261D	DO222775	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.1944
p.E273K	DO222843	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	0.25
p.A272V	DO37519	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.2778
p.S264L	DO37406	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	0.2778
p.M261V	SIDM00845	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	0.1944
p.M261I	SIDM00585	Hepatocellular Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	0.1944
p.M261I	HuH-7	liver	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.1944
p.E272Q	ACH-001127	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	0.2778
p.E272Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.2778
p.M258I	HuH-7	liver	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.1111
p.L269I	NCI-H1666	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.7174
p.R264H	MDST8	large_intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.2778
p.R267H	MDST8	large_intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.8244
p.L266I	NCI-H1666	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.7174
p.P257R	NCI-H1568	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.0833
p.V273F	NCC010	kidney	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.25
p.P270R	NCI-H1568	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.7512
p.V258F	NCC010	kidney	COSMIC	VSSSS	DEG_SPOP_SBC_1	0.1111

Drug responses associated with HDAC9 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000404	Skin Cancer	p.P15S (No)	CCLE	Panobinostat	0.0451
ACH-000404	Skin Cancer	p.P15S (No)	CCLE	Sorafenib	8
ACH-000638	Lung Cancer	p.P23T (No)	CCLE	Panobinostat	0.1213
ACH-000638	Lung Cancer	p.P23T (No)	CCLE	Sorafenib	8
ACH-000945	Lung Cancer	p.M34I (No)	CCLE	Panobinostat	0.1457
ACH-000945	Lung Cancer	p.M34I (No)	CCLE	Sorafenib	8
ACH-000974	Endometrial/Uterine Cancer	p.R119H (No)	CCLE	Panobinostat	0.1365
ACH-000974	Endometrial/Uterine Cancer	p.R119H (No)	CCLE	Sorafenib	8
ACH-000564	Myeloma	p.R136S (No)	CCLE	Panobinostat	0.0189
ACH-000564	Myeloma	p.R136S (No)	CCLE	Sorafenib	4.0152
ACH-000985	Colon/Colorectal Cancer	p.R171H (No)	CCLE	Panobinostat	0.0359
ACH-000985	Colon/Colorectal Cancer	p.R171H (No)	CCLE	Sorafenib	8
ACH-000899	Skin Cancer	p.P142S (No)	CCLE	Panobinostat	0.0953
ACH-000899	Skin Cancer	p.P142S (No)	CCLE	Sorafenib	8
ACH-000019	Breast Cancer	p.H182R (No)	CCLE	Sorafenib	8
ACH-000869	Lung Cancer	p.P221R (No)	CCLE	Panobinostat	0.0588
ACH-000869	Lung Cancer	p.P221R (No)	CCLE	Sorafenib	7.9219
ACH-000448	Lung Cancer	p.L310I (No)	CCLE	Panobinostat	0.0699
ACH-000448	Lung Cancer	p.L310I (No)	CCLE	Sorafenib	8
ACH-000463	Lung Cancer	p.G366V (No)	CCLE	Panobinostat	0.0987
ACH-000463	Lung Cancer	p.G366V (No)	CCLE	Sorafenib	8
ACH-000335	Lung Cancer	p.H378Q (No)	CCLE	Panobinostat	0.0737
ACH-000335	Lung Cancer	p.H378Q (No)	CCLE	Sorafenib	6.9818
ACH-000848	Liver Cancer	p.G415A (No)	CCLE	Panobinostat	0.0567
ACH-000848	Liver Cancer	p.G415A (No)	CCLE	Sorafenib	4.189
ACH-000988	Endometrial/Uterine Cancer	p.R429K (No)	CCLE	Panobinostat	0.0597
ACH-000988	Endometrial/Uterine Cancer	p.R429K (No)	CCLE	Sorafenib	8
ACH-000361	Liver Cancer	p.G433D (No)	CCLE	Panobinostat	0.041
ACH-000361	Liver Cancer	p.G433D (No)	CCLE	Sorafenib	8
ACH-000813	Lung Cancer	p.G356V (No)	CCLE	Panobinostat	0.0737
ACH-000813	Lung Cancer	p.G356V (No)	CCLE	Sorafenib	8
ACH-000643	Breast Cancer	p.R442C (No)	CCLE	Panobinostat	0.0426
ACH-000643	Breast Cancer	p.R442C (No)	CCLE	Sorafenib	8
ACH-000667	Lung Cancer	p.Q475K (No)	CCLE	Panobinostat	0.0689
ACH-000667	Lung Cancer	p.Q475K (No)	CCLE	Sorafenib	8
ACH-000971	Colon/Colorectal Cancer	p.Q510fs (No)	CCLE	Panobinostat	0.0404
ACH-000971	Colon/Colorectal Cancer	p.Q510fs (No)	CCLE	Sorafenib	6.2089
ACH-000766	Lung Cancer	p.G511W (No)	CCLE	Panobinostat	0.0861
ACH-000766	Lung Cancer	p.G511W (No)	CCLE	Sorafenib	8
ACH-000912	Lung Cancer	p.G434V (No)	CCLE	Panobinostat	0.0415
ACH-000912	Lung Cancer	p.G434V (No)	CCLE	Sorafenib	7.0014
ACH-000888	Lung Cancer	p.T527A (No)	CCLE	Sorafenib	8
ACH-000845	Lung Cancer	p.R451M (No)	CCLE	Panobinostat	0.1081
ACH-000845	Lung Cancer	p.R451M (No)	CCLE	Sorafenib	8
ACH-000980	Lung Cancer	p.A614V (No)	CCLE	Panobinostat	0.0455
ACH-000980	Lung Cancer	p.A614V (No)	CCLE	Sorafenib	8
ACH-000962	Ovarian Cancer	p.R670Q (No)	CCLE	Panobinostat	0.138
ACH-000962	Ovarian Cancer	p.R670Q (No)	CCLE	Sorafenib	8
ACH-001145	Ovarian Cancer	p.R670Q (No)	CCLE	Panobinostat	0.12
ACH-001145	Ovarian Cancer	p.R670Q (No)	CCLE	Sorafenib	8
ACH-000065	Leukemia	p.N705S (No)	CCLE	Panobinostat	0.0114
ACH-000065	Leukemia	p.N705S (No)	CCLE	Sorafenib	1.3256
ACH-000053	Lymphoma	p.G709R (No)	CCLE	Panobinostat	0.0623
ACH-000053	Lymphoma	p.G709R (No)	CCLE	Sorafenib	8
ACH-000627	Lung Cancer	p.D739V (No)	CCLE	Panobinostat	0.1041
ACH-000627	Lung Cancer	p.D739V (No)	CCLE	Sorafenib	8
ACH-000879	Endometrial/Uterine Cancer	p.R752H (No)	CCLE	Panobinostat	0.0605
ACH-000879	Endometrial/Uterine Cancer	p.R752H (No)	CCLE	Sorafenib	8
ACH-000811	Ovarian Cancer	p.C757S (No)	CCLE	Panobinostat	0.1414
ACH-000811	Ovarian Cancer	p.C757S (No)	CCLE	Sorafenib	8
ACH-000847	Gastric Cancer	p.D820H (No)	CCLE	Panobinostat	0.0389
ACH-000847	Gastric Cancer	p.D820H (No)	CCLE	Sorafenib	8
ACH-000987	Skin Cancer	p.G867E (No)	CCLE	Panobinostat	0.1065
ACH-000987	Skin Cancer	p.G867E (No)	CCLE	Sorafenib	8
ACH-000322	Skin Cancer	p.G886E (No)	CCLE	Panobinostat	0.088
ACH-000322	Skin Cancer	p.G886E (No)	CCLE	Sorafenib	8
ACH-000966	Ovarian Cancer	p.A915V (No)	CCLE	Panobinostat	0.0954
ACH-000966	Ovarian Cancer	p.A915V (No)	CCLE	Sorafenib	6.6023
ACH-001233	Lung Cancer	p.H956N (No)	CCLE	Panobinostat	0.0081
ACH-001233	Lung Cancer	p.H956N (No)	CCLE	Sorafenib	8
ACH-000900	Lung Cancer	p.G974* (No)	CCLE	Panobinostat	0.0654
ACH-000900	Lung Cancer	p.G974* (No)	CCLE	Sorafenib	8
ACH-000781	Lung Cancer	p.Q987L (No)	CCLE	Panobinostat	0.0933
ACH-000781	Lung Cancer	p.Q987L (No)	CCLE	Sorafenib	8
ACH-000745	Myeloma	p.L1030F (No)	CCLE	Panobinostat	0.018
ACH-000745	Myeloma	p.L1030F (No)	CCLE	Sorafenib	8
ACH-000899	Skin Cancer	p.V1037I (No)	CCLE	Panobinostat	0.0953
ACH-000899	Skin Cancer	p.V1037I (No)	CCLE	Sorafenib	8
ACH-000878	Lung Cancer	p.T1044K (No)	CCLE	Panobinostat	0.0431
ACH-000878	Lung Cancer	p.T1044K (No)	CCLE	Sorafenib	8
ACH-001318	Liver Cancer	p.A1052S (No)	CCLE	Panobinostat	0.0373
ACH-001318	Liver Cancer	p.A1052S (No)	CCLE	Sorafenib	8
ACH-000580	Skin Cancer	p.G1060C (No)	CCLE	Panobinostat	0.5973
ACH-000580	Skin Cancer	p.G1060C (No)	CCLE	Sorafenib	8
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	VNLG/124	8.7182
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	Trichostatin A	0.0873
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	Panobinostat	0.0083
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R260* (Yes)	GDSC	Trichostatin A	0.0167
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R260* (Yes)	GDSC	Panobinostat	0.0024
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	VNLG/124	46.9735
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	Trichostatin A	0.0429
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	Panobinostat	0.0095
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	Panobinostat	0.0334
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	VNLG/124	46.8364
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	Trichostatin A	0.2766
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	Panobinostat	0.058
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	VNLG/124	39.4529
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	Trichostatin A	0.2071
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	Panobinostat	0.0604
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	VNLG/124	34.5964
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	Trichostatin A	0.1391
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	Panobinostat	0.155
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	VNLG/124	38.6195
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	Trichostatin A	0.1967
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	Panobinostat	0.043
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	VNLG/124	16.6724
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	Trichostatin A	0.0608
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	Panobinostat	0.0037
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	VNLG/124	7.6646
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	Trichostatin A	0.0856
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	Panobinostat	0.0066
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	VNLG/124	7.6646
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	Trichostatin A	0.0856
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	Panobinostat	0.0066
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	VNLG/124	10.2625
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	Trichostatin A	0.2111
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	Panobinostat	0.0317
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	VNLG/124	33.0648
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	Trichostatin A	0.3686
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	Panobinostat	0.029
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (No)	GDSC	VNLG/124	8.7182
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (No)	GDSC	Trichostatin A	0.0873
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (No)	GDSC	Panobinostat	0.0083
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	VNLG/124	58.0382
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	Trichostatin A	0.143
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	Panobinostat	0.0482
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	VNLG/124	85.9408
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	Trichostatin A	0.1374
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	Panobinostat	0.0642
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	VNLG/124	54.201
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	Trichostatin A	0.226
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	Panobinostat	0.0496
SIDM00527	COREAD\|large_intestine	p.R311H (No)	GDSC	VNLG/124	61.6904
SIDM00527	COREAD\|large_intestine	p.R311H (No)	GDSC	Trichostatin A	0.2879
SIDM00527	COREAD\|large_intestine	p.R311H (No)	GDSC	Panobinostat	0.025
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	VNLG/124	41.2658
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	Trichostatin A	0.1661
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	Panobinostat	0.0493
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	VNLG/124	18.3585
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	Trichostatin A	0.0166
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	Panobinostat	0.0023
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	VNLG/124	82.2204
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	Trichostatin A	0.9894
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	Panobinostat	0.3117
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	VNLG/124	45.1726
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	Trichostatin A	0.3504
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	Panobinostat	0.1305
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	VNLG/124	45.1726
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	Trichostatin A	0.3504
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	Panobinostat	0.1305
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	VNLG/124	224.5319
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	Trichostatin A	2.0488
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	Panobinostat	0.8585
SIDM00126	SKCM\|melanoma	p.P924S (No)	GDSC	VNLG/124	76.4995
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	VNLG/124	132.7935
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	Trichostatin A	0.8621
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	Panobinostat	0.1676
SIDM00251	STAD\|stomach	p.E304K (No)	GDSC	VNLG/124	21.9133
SIDM00251	STAD\|stomach	p.E304K (No)	GDSC	Trichostatin A	0.1589
SIDM00251	STAD\|stomach	p.E304K (No)	GDSC	Panobinostat	0.111
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	VNLG/124	63.0929
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	Trichostatin A	0.1949
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	Panobinostat	0.0406
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	VNLG/124	46.3341
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	Trichostatin A	0.6267
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	Panobinostat	0.0518
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	VNLG/124	94.0787
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	Trichostatin A	0.2469
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	Panobinostat	0.0601
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	VNLG/124	8.888
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	Trichostatin A	0.0755
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	Panobinostat	0.0106
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	VNLG/124	67.0543
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	Trichostatin A	0.7506
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	Panobinostat	0.0494
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	VNLG/124	43.8004
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	Trichostatin A	0.063
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	Panobinostat	0.0079
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.H657Y (No)	GDSC	VNLG/124	16.7018
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.H657Y (No)	GDSC	Trichostatin A	0.0906
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	VNLG/124	26.9059
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	Trichostatin A	0.1294
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	Panobinostat	0.0165
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	VNLG/124	23.0783
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	Trichostatin A	0.1961
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	Panobinostat	0.0139
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	VNLG/124	38.0701
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	Trichostatin A	0.0681
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	Panobinostat	0.029
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	VNLG/124	69.5809
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	Trichostatin A	0.4566
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	Panobinostat	0.2065
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	VNLG/124	69.5809
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	Trichostatin A	0.4566
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	Panobinostat	0.2065
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	VNLG/124	19.5974
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	Trichostatin A	0.0572
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	Panobinostat	0.021
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	VNLG/124	22.6152
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	Trichostatin A	0.0798
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	Panobinostat	0.008
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	VNLG/124	42.2889
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	Trichostatin A	0.1885
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	Panobinostat	0.0494
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	VNLG/124	12.6789
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	Trichostatin A	0.402
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	Panobinostat	0.0672
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	VNLG/124	68.3252
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	Trichostatin A	0.1939
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	Panobinostat	0.0959
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	VNLG/124	59.6889
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	Trichostatin A	0.2542
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	Panobinostat	0.0291
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	VNLG/124	140.7267
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	Trichostatin A	24.6674
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	Panobinostat	26.5314
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	VNLG/124	140.7267
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	Trichostatin A	24.6674
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	Panobinostat	26.5314
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	VNLG/124	66.551
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	Trichostatin A	0.5086
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	Panobinostat	0.1247
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	VNLG/124	66.551
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	Trichostatin A	0.5086
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	Panobinostat	0.1247
SIDM00640	MESO\|mesothelioma	p.H381Q (No)	GDSC	VNLG/124	41.3922
SIDM00640	MESO\|mesothelioma	p.H381Q (No)	GDSC	Trichostatin A	0.3737
SIDM00640	MESO\|mesothelioma	p.H381Q (No)	GDSC	Panobinostat	0.1272
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	VNLG/124	50.1704
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	Trichostatin A	0.0489
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	Panobinostat	0.0104
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	VNLG/124	74.7738
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	Trichostatin A	0.2465
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	Panobinostat	0.0604
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.A142T (No)	GDSC	VNLG/124	28.523
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	VNLG/124	46.9735
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	Trichostatin A	0.0429
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	Panobinostat	0.0095
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	VNLG/124	142.837
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	Trichostatin A	0.2496
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	Panobinostat	0.0667
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	VNLG/124	4.9582
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	Trichostatin A	0.0887
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	Panobinostat	0.0171
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	VNLG/124	91.025
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	Trichostatin A	0.2171
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	Panobinostat	0.0472
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	Panobinostat	0.1073
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	VNLG/124	91.0538
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	Trichostatin A	0.971
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	Panobinostat	0.0967
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	VNLG/124	107.9185
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	Trichostatin A	0.1623
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	Panobinostat	0.0685
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	VNLG/124	79.1092
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	Trichostatin A	0.1509
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	Panobinostat	0.2047
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	Panobinostat	0.0334
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	Panobinostat	0.0334
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	VNLG/124	104.0033
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	Trichostatin A	0.2261
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	Panobinostat	0.1004
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	VNLG/124	56.1435
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	Trichostatin A	0.3061
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	Panobinostat	0.0618
SIDM00585	LIHC\|liver	p.M261I (Yes)	GDSC	VNLG/124	76.4064
SIDM00585	LIHC\|liver	p.M261I (Yes)	GDSC	Trichostatin A	1.1925
SIDM00585	LIHC\|liver	p.M261I (Yes)	GDSC	Panobinostat	1.0336
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	VNLG/124	77.3108
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	Trichostatin A	0.6175
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	Panobinostat	0.0997
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	VNLG/124	77.3108
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	Trichostatin A	0.6175
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	Panobinostat	0.0997
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	VNLG/124	21.5926
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	Trichostatin A	0.0698
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	Panobinostat	0.0235
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	VNLG/124	22.0655
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	Trichostatin A	0.4753
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	Panobinostat	0.0806
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	VNLG/124	68.4196
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	Trichostatin A	0.0415
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	Panobinostat	0.0151
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G1027R (No)	GDSC	Trichostatin A	0.0487
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G1027R (No)	GDSC	Panobinostat	0.017
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (No)	GDSC	VNLG/124	54.6187
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (No)	GDSC	Trichostatin A	0.2516
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (No)	GDSC	Panobinostat	0.0764
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (No)	GDSC	VNLG/124	75.2076
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (No)	GDSC	Trichostatin A	10.7702
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (No)	GDSC	Panobinostat	0.5964
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	VNLG/124	91.0599
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	Trichostatin A	0.2467
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	Panobinostat	0.156
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	VNLG/124	61.3947
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	Trichostatin A	0.4604
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	Panobinostat	0.299
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	VNLG/124	195.3063
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	Trichostatin A	1.3676
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	Panobinostat	0.5473
SIDM00383	UNCLASSIFIED\|stomach	p.A625V (No)	GDSC	VNLG/124	45.1114
SIDM00383	UNCLASSIFIED\|stomach	p.A625V (No)	GDSC	Trichostatin A	0.0528
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	VNLG/124	121.3447
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	Trichostatin A	0.38
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	Panobinostat	0.0399
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	VNLG/124	34.5057
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	Trichostatin A	0.2205
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	Panobinostat	0.2424
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	VNLG/124	53.5821
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	Trichostatin A	0.021
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	Panobinostat	0.0261
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	VNLG/124	20.4972
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	Trichostatin A	0.1897
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	Panobinostat	0.0684
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	VNLG/124	91.525
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	Trichostatin A	0.3886
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	Panobinostat	0.0311
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	VNLG/124	43.7393
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	Trichostatin A	0.7903
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	Panobinostat	0.3669
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	VNLG/124	28.4171
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	Trichostatin A	0.374
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	Panobinostat	0.0678
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	VNLG/124	84.9584
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	Trichostatin A	1.0881
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	Panobinostat	0.0976
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	VNLG/124	44.3849
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	Trichostatin A	0.1199
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	Panobinostat	0.0176
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	VNLG/124	132.1749
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	Trichostatin A	0.3336
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	Panobinostat	0.1051
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	VNLG/124	132.1749
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	Trichostatin A	0.3336
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	Panobinostat	0.1051
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	VNLG/124	50.3006
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	Trichostatin A	0.172
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	Panobinostat	0.0443

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	745:749	VSSSS	SPOP	0.8267	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	820:824	VSSSS	SPOP	0.967	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	646:650	VSSSS	SPOP	0.7785	More...
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	388:392	VSSSS	SPOP	0.9965	More...
O60315	Zinc finger E-box-binding homeobox 2	DEG_SPOP_SBC_1	849:853	VSSSS	SPOP	0.9885	More...
O60447	Ecotropic viral integration site 5 protein homolog	DEG_SPOP_SBC_1	118:122	VSSSS	SPOP	0.9992	More...
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1143:1147	VSSSS	SPOP	0.984	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	595:599	VSSSS	SPOP	0.9481	More...
O95197	Reticulon-3	DEG_SPOP_SBC_1	51:55	VSSSS	SPOP	0.5294	More...
P08670	Vimentin	DEG_SPOP_SBC_1	6:10	VSSSS	SPOP	0.9968	More...
P08727	Keratin, type I cytoskeletal 19	DEG_SPOP_SBC_1	53:57	VSSSS	SPOP	0.8181	More...
P20823	Hepatocyte nuclear factor 1-alpha	DEG_SPOP_SBC_1	590:594	VSSSS	SPOP	0.9502	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	113:117	VSSSS	SPOP	0.9903	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1737:1741	VSSSS	SPOP	0.9969	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	907:911	VSSSS	SPOP	0.9975	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1365:1369	VSSSS	SPOP	0.9892	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	2238:2242	VSSSS	SPOP	0.9963	More...
P53999	Activated RNA polymerase II transcriptional coactivator p15	DEG_SPOP_SBC_1	8:12	VSSSS	SPOP	0.9826	More...
P56715	Oxygen-regulated protein 1	DEG_SPOP_SBC_1	1686:1690	VSSSS	SPOP	0.9538	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2660:2664	VSSSS	SPOP	0.9717	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	474:478	VSSSS	SPOP	0.972	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1226:1230	VSSSS	SPOP	0.9333	More...
Q06710	Paired box protein Pax-8	DEG_SPOP_SBC_1	314:318	VSSSS	SPOP	0.9913	More...
Q10571	Transcriptional activator MN1	DEG_SPOP_SBC_1	1059:1063	VSSSS	SPOP	0.9938	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	325:329	VSSSS	SPOP	0.9847	More...
Q13641	Trophoblast glycoprotein	DEG_SPOP_SBC_1	29:33	VSSSS	SPOP	0.7118	More...
Q16836	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	DEG_SPOP_SBC_1	12:16	VSSSS	SPOP	0.5131	More...
Q2V2M9	FH1/FH2 domain-containing protein 3	DEG_SPOP_SBC_1	630:634	VSSSS	SPOP	0.9871	More...
Q496A3	Spermatogenesis-associated serine-rich protein 1	DEG_SPOP_SBC_1	70:74	VSSSS	SPOP	0.9801	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1096:1100	VSSSS	SPOP	0.9544	More...
Q68DC2	Ankyrin repeat and SAM domain-containing protein 6	DEG_SPOP_SBC_1	752:756	VSSSS	SPOP	0.9841	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1277:1281	VSSSS	SPOP	0.9565	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_SPOP_SBC_1	1060:1064	VSSSS	SPOP	0.9641	More...
Q6PCD5	E3 ubiquitin-protein ligase RFWD3	DEG_SPOP_SBC_1	210:214	VSSSS	SPOP	0.6762	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	61:65	VSSSS	SPOP	0.7564	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	135:139	VSSSS	SPOP	0.9764	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	580:584	VSSSS	SPOP	0.9616	More...
Q7Z3E5	LisH domain-containing protein ARMC9	DEG_SPOP_SBC_1	707:711	VSSSS	SPOP	0.992	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	614:618	VSSSS	SPOP	0.9887	More...
Q86YJ7	Ankyrin repeat domain-containing protein 13B	DEG_SPOP_SBC_1	464:468	VSSSS	SPOP	0.9801	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	924:928	VSSSS	SPOP	0.9158	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	348:352	VSSSS	SPOP	0.9933	More...
Q8NFM7	Interleukin-17 receptor D	DEG_SPOP_SBC_1	696:700	VSSSS	SPOP	0.9954	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	592:596	VSSSS	SPOP	0.9857	More...
Q8TEC5	E3 ubiquitin-protein ligase SH3RF2	DEG_SPOP_SBC_1	274:278	VSSSS	SPOP	0.9926	More...
Q8TF01	Arginine/serine-rich protein PNISR	DEG_SPOP_SBC_1	531:535	VSSSS	SPOP	0.99	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9437:9441	VSSSS	SPOP	0.9436	More...
Q96A56	Tumor protein p53-inducible nuclear protein 1	DEG_SPOP_SBC_1	13:17	VSSSS	SPOP	0.5189	More...
Q96CN4	EVI5-like protein	DEG_SPOP_SBC_1	70:74	VSSSS	SPOP	0.6625	More...
Q96CN9	GRIP and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	140:144	VSSSS	SPOP	0.8322	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	843:847	VSSSS	SPOP	0.9898	More...
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_SPOP_SBC_1	1595:1599	VSSSS	SPOP	0.9925	More...
Q96S65	Cysteine/serine-rich nuclear protein 1	DEG_SPOP_SBC_1	19:23	VSSSS	SPOP	0.9896	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	219:223	VSSSS	SPOP	0.5809	More...
Q9C004	Protein sprouty homolog 4	DEG_SPOP_SBC_1	99:103	VSSSS	SPOP	0.9969	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1138:1142	VSSSS	SPOP	0.995	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1097:1101	VSSSS	SPOP	0.9942	More...
Q9H040	DNA-dependent metalloprotease SPRTN	DEG_SPOP_SBC_1	364:368	VSSSS	SPOP	0.9992	More...
Q9NRF2	SH2B adapter protein 1	DEG_SPOP_SBC_1	137:141	VSSSS	SPOP	0.9967	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	824:828	VSSSS	SPOP	0.9843	More...
Q9P278	Folliculin-interacting protein 2	DEG_SPOP_SBC_1	98:102	VSSSS	SPOP	0.9898	More...
Q9UHL9	General transcription factor II-I repeat domain-containing protein 1	DEG_SPOP_SBC_1	911:915	VSSSS	SPOP	0.9873	More...
Q9UKV0	Histone deacetylase 9	DEG_SPOP_SBC_1	266:270	VSSSS	SPOP	0.9845	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	350:354	VSSSS	SPOP	0.981	More...
Q9UPN6	SR-related and CTD-associated factor 8	DEG_SPOP_SBC_1	834:838	VSSSS	SPOP	0.931	More...
Q9UPQ0	LIM and calponin homology domains-containing protein 1	DEG_SPOP_SBC_1	834:838	VSSSS	SPOP	0.9719	More...
Q9Y2L5	Trafficking protein particle complex subunit 8	DEG_SPOP_SBC_1	1125:1129	VSSSS	SPOP	0.5281	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	767:771	VSSSS	SPOP	0.9948	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	86:90	VSSSS	SPOP	0.9889	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1115:1119	VSSSS	SPOP	0.9844	More...
Q13203	Myosin-binding protein H	DEG_SPOP_SBC_1	82:86	VSSSS	SPOP	0.5759	More...
Q5VTQ0	Tetratricopeptide repeat protein 39B	DEG_SPOP_SBC_1	122:126	VSSSS	SPOP	0.7044	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	681:685	VSSSS	SPOP	0.8869	More...
Q96GY0	Zinc finger C2HC domain-containing protein 1A	DEG_SPOP_SBC_1	208:212	VSSSS	SPOP	0.9983	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SPOP_SBC_1	1262:1266	VSSSS	SPOP	0.9992	More...
Q99742	Neuronal PAS domain-containing protein 1	DEG_SPOP_SBC_1	213:217	VSSSS	SPOP	0.8715	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	1263:1267	VSSSS	SPOP	0.9997	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SPOP_SBC_1	1262:1266	VSSSS	SPOP	0.9995	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	1247:1251	VSSSS	SPOP	0.999	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	1255:1259	VSSSS	SPOP	0.9939	More...
Q32P51	Heterogeneous nuclear ribonucleoprotein A1-like 2	DEG_SPOP_SBC_1	307:311	VSSSS	SPOP	0.9897	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_SPOP_SBC_1	7:11	VSSSS	SPOP	0.9195	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	897:901	VSSSS	SPOP	0.9592	More...
Q6ZWB6	BTB/POZ domain-containing protein KCTD8	DEG_SPOP_SBC_1	20:24	VSSSS	SPOP	0.9622	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SPOP_SBC_1	1263:1267	VSSSS	SPOP	0.995	More...
Q96N46	Tetratricopeptide repeat protein 14	DEG_SPOP_SBC_1	488:492	VSSSS	SPOP	0.9738	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	2347:2351	VSSSS	SPOP	0.7666	More...
Q9P2B7	Cilia- and flagella-associated protein 97	DEG_SPOP_SBC_1	169:173	VSSSS	SPOP	0.9947	More...
A4D263	Spermatogenesis-associated protein 48	DEG_SPOP_SBC_1	313:317	VSSSS	SPOP	0.5985	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8843	More...
A6NE21		DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9592	More...
A6NEW6		DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8989	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	427:431	VSSSS	SPOP	0.986	More...
A6NIJ5	Putative protein FAM90A20P	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9636	More...
A6NJQ4	Putative protein FAM90A8	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9647	More...
A6NKC0	Putative protein FAM90A7	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9592	More...
A6NNJ1	Putative protein FAM90A9	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8064	More...
A8MWA6	Putative protein FAM90A22	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9841	More...
A8MX19	Putative protein FAM90A12P	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8989	More...
A8MXJ8	Putative protein FAM90A5P	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8961	More...
A8MXZ1	Putative protein FAM90A23	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9647	More...
D6RGX4	Putative protein FAM90A26	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.902	More...
P0C7V4	Putative protein FAM90A15P	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9636	More...
P0C7W8	Putative protein FAM90A13P	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9636	More...
P0C7W9	Putative protein FAM90A14	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.9636	More...
P0C7X0	Putative protein FAM90A24P	DEG_SPOP_SBC_1	452:456	VSSSS	SPOP	0.8989	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1306:1310	VSSSS	SPOP	0.995	More...
Q658T7	Putative protein FAM90A2P	DEG_SPOP_SBC_1	451:455	VSSSS	SPOP	0.9777	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	627:631	VSSSS	SPOP	0.6008	More...
Q96GX8	Uncharacterized protein C16orf74	DEG_SPOP_SBC_1	15:19	VSSSS	SPOP	0.8333	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSSS

Degron related mutations and impact score

Drug responses associated with HDAC9 mutations

All proteins holding degron of VSSSS