DegronMD

Uniprot ID: Q06710

Source protein: Paired box protein Pax-8

Source gene: PAX8

Class: DEG_SCF_FBW7_1

Location: 165:170

E3 ligase: FBXW7

DEGRON score: 0.9827

ASA_SCORE: 76.25

COIL: 0.9637

CONS_SCORE: 0.6468

DSS_SCORE: 0.6397

HELIX: 0.0118

FCONS_SCORE: 0.9668

RIG_SCORE: 0.6211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P161R	TCGA-25-2393	OV	TCGA	VTPPES	DEG_SCF_FBW7_1	0.2222
p.P161R	DO32153	OV	ICGC	VTPPES	DEG_SCF_FBW7_1	0.2222
p.P155H	TCGA-2Z-A9JG	KIRP	TCGA	VTPPES	DEG_SCF_FBW7_1	0.0556
p.P155H	DO219667	KIRP	ICGC	VTPPES	DEG_SCF_FBW7_1	0.0556
p.A164D	TCGA-66-2785	LUSC	TCGA	VTPPES	DEG_SCF_FBW7_1	0.3056
p.A164D	DO26520	LUSC	ICGC	VTPPES	DEG_SCF_FBW7_1	0.3056
p.Y180H	TCGA-AA-3815	COAD	TCGA	VTPPES	DEG_SCF_FBW7_1	0.0556
p.Y180H	DO9924	COAD	ICGC	VTPPES	DEG_SCF_FBW7_1	0.0556
p.P155S	TCGA-FR-A726	SKCM	TCGA	VTPPES	DEG_SCF_FBW7_1	0.0556
p.P155S	DO48665	SKCM	ICGC	VTPPES	DEG_SCF_FBW7_1	0.0556
p.P161S	TCGA-FW-A3R5	SKCM	TCGA	VTPPES	DEG_SCF_FBW7_1	0.2222
p.P161S	DO37406	SKCM	ICGC	VTPPES	DEG_SCF_FBW7_1	0.2222
p.P167S	DO222880	MELA	ICGC	VTPPES	DEG_SCF_FBW7_1	0.6752
p.A164V	DO33552	PACA	ICGC	VTPPES	DEG_SCF_FBW7_1	0.3056
p.D174N	DO232761	PBCA	ICGC	VTPPES	DEG_SCF_FBW7_1	0.2222
p.Y180C	SIDM01608	Endometrial Carcinoma	GDSC	VTPPES	DEG_SCF_FBW7_1	0.0556
p.Y180C	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTPPES	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06710	Paired box protein Pax-8	DEG_SCF_FBW7_1	165:170	VTPPES	FBXW7	0.9827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons