DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LRRVLAELN
Uniprot ID:
Q9H6W3
Source protein:
Ribosomal oxygenase 1
Source gene:
RIOX1
Class:
DEG_APCC_DBOX_1
Location:
185:193
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7052
ASA_SCORE:
85.1333
COIL:
0.2437
CONS_SCORE:
0.2864
DSS_SCORE:
0.3414
HELIX:
0.7504
FCONS_SCORE:
0.8923
RIG_SCORE:
0.8183
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RIOX1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRRVLAELN
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6W3
Ribosomal oxygenase 1
DEG_APCC_DBOX_1
185:193
LRRVLAELN
APC,CDC20,FZR1
0.7052
More...