DegronMD

Uniprot ID: Q7Z4F1

Source protein: Low-density lipoprotein receptor-related protein 10

Source gene: LRP10

Class: DEG_APCC_DBOX_1

Location: 525:533

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.679

ASA_SCORE: 71.4333

COIL: 0.4817

CONS_SCORE: 0.4899

DSS_SCORE: 0.4868

HELIX: 0.41

FCONS_SCORE: 1.1029

RIG_SCORE: 0.8108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R526H	TCGA-AA-3877	COAD	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	0.8244
p.R526H	TCGA-L5-A4OI	ESCA	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	0.8244
p.R526H	DO7855	COAD	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	0.8244
p.R526C	TCGA-AZ-4315	COAD	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	0.8301
p.R526C	DO8842	COAD	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	0.8301
p.S527F	TCGA-EL-A3CT	THCA	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	0.6871
p.S527F	DO48113	THCA	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	0.6871
p.N517D	TCGA-J2-A4AD	LUAD	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	0.1111
p.N517D	DO23915	LUAD	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	0.1111
p.D518N	SIDM00615	Hepatocellular Carcinoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.1389
p.D518N	SIDM00617	Hepatocellular Carcinoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.1389
p.D518N	SIDM00157	Neuroblastoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.1389
p.D518N	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.1389
p.D518N	SIDM00982	Glioblastoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.1389
p.D518N	SIDM01464	Pancreatic Carcinoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.1389
p.P516T	SIDM00256	Neuroblastoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	0.0833
p.P516T	ACH-002281	Neuroblastoma	CCLE	LRSLLQILR	DEG_APCC_DBOX_1	0.0833
p.P516T	NB14	autonomic_ganglia	COSMIC	LRSLLQILR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4F1	Low-density lipoprotein receptor-related protein 10	DEG_APCC_DBOX_1	525:533	LRSLLQILR	APC,CDC20,FZR1	0.679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons