DegronMD - Q7Z4F1(LRP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R526H	TCGA-AA-3877	COAD	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.8244
p.R526H	TCGA-L5-A4OI	ESCA	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.8244
p.R526H	DO7855	COAD	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.8244
p.R88C	TCGA-AJ-A3OK	UCEC	TCGA	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8301
p.R88C	DO43602	UCEC	ICGC	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8301
p.R88C	SIDM00932	Kidney Carcinoma	GDSC	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8301
p.R88C	ACH-000457	Kidney Cancer	CCLE	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8301
p.R88C	CAL-54	kidney	COSMIC	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8301
p.R526C	TCGA-AZ-4315	COAD	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.8301
p.R526C	DO8842	COAD	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.8301
p.S527F	TCGA-EL-A3CT	THCA	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.6871
p.S527F	DO48113	THCA	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation altering degron motif	0.6871
p.N517D	TCGA-J2-A4AD	LUAD	TCGA	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1111
p.N517D	DO23915	LUAD	ICGC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1111
p.R84H	TCGA-VQ-A8P2	STAD	TCGA	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.R84H	DO51761	STAD	ICGC	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.D518N	SIDM00615	Hepatocellular Carcinoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1389
p.D518N	SIDM00617	Hepatocellular Carcinoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1389
p.D518N	SIDM00157	Neuroblastoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1389
p.D518N	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1389
p.D518N	SIDM00982	Glioblastoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1389
p.D518N	SIDM01464	Pancreatic Carcinoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.1389
p.P516T	SIDM00256	Neuroblastoma	GDSC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.0833
p.P516T	ACH-002281	Neuroblastoma	CCLE	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.0833
p.P516T	NB14	autonomic ganglia	COSMIC	LRSLLQILR	DEG_APCC_DBOX_1	525:533	Mutation rewiring degron network	0.0833
p.L87V	SIDM01409	Bladder Carcinoma	GDSC	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.5654
p.L87V	ACH-000834	Bladder Cancer	CCLE	LRSPLQPLI	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.5654

Kaplan plot for LRP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP10

UniProt ID: Q7Z4F1

Entrez ID: 26020

Protein name: Low-density lipoprotein receptor-related protein 10 (LRP-10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP10 in