DegronMD

Uniprot ID: Q7Z4F1

Source protein: Low-density lipoprotein receptor-related protein 10

Source gene: LRP10

Class: DEG_APCC_DBOX_1

Location: 87:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.761

ASA_SCORE: 77.3889

COIL: 0.8357

CONS_SCORE: 0.4716

DSS_SCORE: 0.1944

HELIX: 0.0934

FCONS_SCORE: 0.8147

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R88C	TCGA-AJ-A3OK	UCEC	TCGA	LRSPLQPLI	DEG_APCC_DBOX_1	0.8301
p.R88C	DO43602	UCEC	ICGC	LRSPLQPLI	DEG_APCC_DBOX_1	0.8301
p.R88C	SIDM00932	Kidney Carcinoma	GDSC	LRSPLQPLI	DEG_APCC_DBOX_1	0.8301
p.R88C	ACH-000457	Kidney Cancer	CCLE	LRSPLQPLI	DEG_APCC_DBOX_1	0.8301
p.R88C	CAL-54	kidney	COSMIC	LRSPLQPLI	DEG_APCC_DBOX_1	0.8301
p.R84H	TCGA-VQ-A8P2	STAD	TCGA	LRSPLQPLI	DEG_APCC_DBOX_1	0.25
p.R84H	DO51761	STAD	ICGC	LRSPLQPLI	DEG_APCC_DBOX_1	0.25
p.L87V	SIDM01409	Bladder Carcinoma	GDSC	LRSPLQPLI	DEG_APCC_DBOX_1	0.5654
p.L87V	ACH-000834	Bladder Cancer	CCLE	LRSPLQPLI	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4F1	Low-density lipoprotein receptor-related protein 10	DEG_APCC_DBOX_1	87:95	LRSPLQPLI	APC,CDC20,FZR1	0.761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons