DegronMD

Uniprot ID: P51798

Source protein: H

Source gene: CLCN7

Class: DEG_APCC_DBOX_1

Location: 680:688

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6599

ASA_SCORE: 26.5

COIL: 0.0306

CONS_SCORE: 0.5422

DSS_SCORE: 0.0238

HELIX: 0.9437

FCONS_SCORE: 1.4533

RIG_SCORE: 0.9098

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q676H	TCGA-AZ-6598	COAD	TCGA	LRSQLIVLL	DEG_APCC_DBOX_1	0.2222
p.R681H	TCGA-EO-A22R	UCEC	TCGA	LRSQLIVLL	DEG_APCC_DBOX_1	0.8244
p.R674Q	TCGA-EY-A549	UCEC	TCGA	LRSQLIVLL	DEG_APCC_DBOX_1	0.1667
p.I697M	DO472	BLCA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.0833
p.R680W	DO51733	COAD	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.8634
p.L677P	DO51734	COAD	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.25
p.R672Q	DO227987	COCA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.1111
p.A690T	DO233898	GACA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.2778
p.A690T	DO233823	GACA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.2778
p.V670M	DO228941	LICA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.0556
p.L682M	DO27889	ORCA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.711
p.A690V	DO42312	UCEC	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51798	H	DEG_APCC_DBOX_1	680:688	LRSQLIVLL	APC,CDC20,FZR1	0.6599	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons