DegronMD - P51798(CLCN7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q676H	TCGA-AZ-6598	COAD	TCGA	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.2222
p.S61G	TCGA-BS-A0UV	UCEC	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.6667
p.S61G	DO42793	UCEC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.6667
p.S61N	TCGA-CZ-5468	KIRC	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.6667
p.S61N	DO18332	KIRC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.6667
p.R50C	TCGA-DF-A2KU	UCEC	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.8301
p.R50C	DO223286	UCEC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.8301
p.R681H	TCGA-EO-A22R	UCEC	TCGA	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation altering degron motif	0.8244
p.R674Q	TCGA-EY-A549	UCEC	TCGA	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.1667
p.G57A	TCGA-ZF-AA4X	BLCA	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6429
p.G57A	DO219091	BLCA	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6429
p.I697M	DO472	BLCA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.0833
p.S67C	DO50026	BRCA	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0556
p.R680W	DO51733	COAD	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation altering degron motif	0.8634
p.L677P	DO51734	COAD	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.25
p.R672Q	DO227987	COCA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.1111
p.A690T	DO233898	GACA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.2778
p.A690T	DO233823	GACA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.2778
p.V670M	DO228941	LICA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.0556
p.F55L	DO50094	LUSC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6981
p.L682M	DO27889	ORCA	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation altering degron motif	0.711
p.D50N	DO38081	SKCM	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6932
p.A690V	DO42312	UCEC	ICGC	LRSQLIVLL	DEG_APCC_DBOX_1	680:688	Mutation rewiring degron network	0.2778
p.K57N	DO41999	UCEC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6918
p.S51F	ACH-000429	Kidney Cancer	CCLE	PRSALFRVG	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6871

Kaplan plot for CLCN7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCN7

UniProt ID: P51798

Entrez ID: 1186

Protein name: H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCN7 in