DegronMD

Uniprot ID: P51798

Source protein: H

Source gene: CLCN7

Class: DEG_APCC_DBOX_1

Location: 49:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9979

ASA_SCORE: 76.1222

COIL: 0.7393

CONS_SCORE: 0.2963

DSS_SCORE: 0.556

HELIX: 0.1811

FCONS_SCORE: 1.083

RIG_SCORE: 0.6835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S61G	TCGA-BS-A0UV	UCEC	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	0.6667
p.S61G	DO42793	UCEC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.6667
p.S61N	TCGA-CZ-5468	KIRC	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	0.6667
p.S61N	DO18332	KIRC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.6667
p.R50C	TCGA-DF-A2KU	UCEC	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	0.8301
p.R50C	DO223286	UCEC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.8301
p.G57A	TCGA-ZF-AA4X	BLCA	TCGA	PRSALFRVG	DEG_APCC_DBOX_1	0.6429
p.G57A	DO219091	BLCA	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.6429
p.S67C	DO50026	BRCA	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.0556
p.F55L	DO50094	LUSC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.6981
p.D50N	DO38081	SKCM	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.6932
p.K57N	DO41999	UCEC	ICGC	PRSALFRVG	DEG_APCC_DBOX_1	0.6918
p.S51F	ACH-000429	Kidney Cancer	CCLE	PRSALFRVG	DEG_APCC_DBOX_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51798	H	DEG_APCC_DBOX_1	49:57	PRSALFRVG	APC,CDC20,FZR1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons