DegronMD

Uniprot ID: Q8N998

Source protein: Coiled-coil domain-containing protein 89

Source gene: CCDC89

Class: DEG_APCC_DBOX_1

Location: 229:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8836

ASA_SCORE: 85.0444

COIL: 0.0319

CONS_SCORE: 0.5385

DSS_SCORE: 0.4429

HELIX: 0.968

FCONS_SCORE: 1.2531

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H240L	TCGA-17-Z026	LUAD	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	0.25
p.Q234L	TCGA-44-2659	LUAD	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	0.6654
p.Q234L	DO23744	LUAD	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	0.6654
p.Q242L	TCGA-50-5930	LUAD	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	0.1944
p.Q242L	DO25189	LUAD	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	0.1944
p.R230C	TCGA-AP-A0LM	UCEC	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	0.8301
p.R230C	DO43306	UCEC	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	0.8301
p.E245K	TCGA-D3-A8GL	SKCM	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	0.1111
p.E245K	DO50287	SKCM	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	0.1111
p.K237N	TCGA-EO-A3AV	UCEC	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	0.5806
p.K237N	DO52412	UCEC	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	0.5806
p.T223I	DO222702	MELA	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	0.1667
p.A219D	SIDM00636	Non-Cancerous	GDSC	LRSQLQTLK	DEG_APCC_DBOX_1	0.0556
p.A219D	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	LRSQLQTLK	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N998	Coiled-coil domain-containing protein 89	DEG_APCC_DBOX_1	229:237	LRSQLQTLK	APC,CDC20,FZR1	0.8836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons