DegronMD - Q8N998(CCDC89)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H240L	TCGA-17-Z026	LUAD	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.25
p.Q234L	TCGA-44-2659	LUAD	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6654
p.Q234L	DO23744	LUAD	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6654
p.L6F	TCGA-50-5066	LUAD	TCGA	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.1111
p.L6F	DO25040	LUAD	ICGC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.1111
p.Q242L	TCGA-50-5930	LUAD	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1944
p.Q242L	DO25189	LUAD	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1944
p.R230C	TCGA-AP-A0LM	UCEC	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8301
p.R230C	DO43306	UCEC	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8301
p.E245K	TCGA-D3-A8GL	SKCM	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1111
p.E245K	DO50287	SKCM	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1111
p.K237N	TCGA-EO-A3AV	UCEC	TCGA	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5806
p.K237N	DO52412	UCEC	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5806
p.M14L	TCGA-V4-A9F8	UVM	TCGA	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.5999
p.P17T	DO229018	LICA	ICGC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7031
p.T223I	DO222702	MELA	ICGC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.P19L	DO222843	MELA	ICGC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.6471
p.M14I	DO51962	PRAD	ICGC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.6507
p.D15H	DO51962	PRAD	ICGC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.6577
p.A11T	DO229234	THCA	ICGC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.25
p.T16A	SIDM00373	Endometrial Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	SIDM01146	Gastric Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	SIDM00784	Glioma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	SIDM01587	Bladder Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	SNG-M	endometrium	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	ABC-1	lung	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.T16A	NCI-SNU-1	stomach	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation altering degron motif	0.7139
p.E24D	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.2222
p.E24D	ACH-000766	Lung Cancer	CCLE	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.2222
p.E24D	NCI-H1648	lung	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.2222
p.A219D	SIDM00636	Non-Cancerous	GDSC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.0556
p.A219D	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	LRSQLQTLK	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.0556
p.Q9R	SIDM01121	Small Cell Lung Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation substituting flanking lysine	0.3056
p.Q9R	ACH-000358	Lung Cancer	CCLE	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation substituting flanking lysine	0.3056
p.Q9R	NCI-H69	lung	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation substituting flanking lysine	0.3056
p.M5I	SIDM00528	Breast Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation substituting flanking lysine	0.1944
p.M5I	ACH-000934	Breast Cancer	CCLE	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation substituting flanking lysine	0.1944
p.M5I	MDA-MB-361	breast	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation substituting flanking lysine	0.1944
p.E21G	ACH-000937	Leukemia	CCLE	MDTPPPE	DEG_SCF_FBW7_2	14:20	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC89

UniProt ID: Q8N998

Entrez ID: 220388

Protein name: Coiled-coil domain-containing protein 89 (Bc8 orange-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC89 in