DegronMD

Uniprot ID: Q8N998

Source protein: Coiled-coil domain-containing protein 89

Source gene: CCDC89

Class: DEG_SCF_FBW7_2

Location: 14:20

E3 ligase: FBXW7

DEGRON score: 0.9693

ASA_SCORE: 92.8571

COIL: 0.7674

CONS_SCORE: 0.2926

DSS_SCORE: 0.8747

HELIX: 0.2153

FCONS_SCORE: 1.1445

RIG_SCORE: 0.5767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L6F	TCGA-50-5066	LUAD	TCGA	MDTPPPE	DEG_SCF_FBW7_2	0.1111
p.L6F	DO25040	LUAD	ICGC	MDTPPPE	DEG_SCF_FBW7_2	0.1111
p.M14L	TCGA-V4-A9F8	UVM	TCGA	MDTPPPE	DEG_SCF_FBW7_2	0.5999
p.P17T	DO229018	LICA	ICGC	MDTPPPE	DEG_SCF_FBW7_2	0.7031
p.P19L	DO222843	MELA	ICGC	MDTPPPE	DEG_SCF_FBW7_2	0.6471
p.M14I	DO51962	PRAD	ICGC	MDTPPPE	DEG_SCF_FBW7_2	0.6507
p.D15H	DO51962	PRAD	ICGC	MDTPPPE	DEG_SCF_FBW7_2	0.6577
p.A11T	DO229234	THCA	ICGC	MDTPPPE	DEG_SCF_FBW7_2	0.25
p.T16A	SIDM00373	Endometrial Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	SIDM01146	Gastric Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	SIDM00784	Glioma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	SIDM01587	Bladder Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	SNG-M	endometrium	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	ABC-1	lung	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.T16A	NCI-SNU-1	stomach	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	0.7139
p.E24D	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.2222
p.E24D	ACH-000766	Lung Cancer	CCLE	MDTPPPE	DEG_SCF_FBW7_2	0.2222
p.E24D	NCI-H1648	lung	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	0.2222
p.Q9R	SIDM01121	Small Cell Lung Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.3056
p.Q9R	ACH-000358	Lung Cancer	CCLE	MDTPPPE	DEG_SCF_FBW7_2	0.3056
p.Q9R	NCI-H69	lung	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	0.3056
p.M5I	SIDM00528	Breast Carcinoma	GDSC	MDTPPPE	DEG_SCF_FBW7_2	0.1944
p.M5I	ACH-000934	Breast Cancer	CCLE	MDTPPPE	DEG_SCF_FBW7_2	0.1944
p.M5I	MDA-MB-361	breast	COSMIC	MDTPPPE	DEG_SCF_FBW7_2	0.1944
p.E21G	ACH-000937	Leukemia	CCLE	MDTPPPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N998	Coiled-coil domain-containing protein 89	DEG_SCF_FBW7_2	14:20	MDTPPPE	FBXW7	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MDTPPPE

Degron related mutations and impact score

Drug responses associated with CCDC89 mutations

All proteins holding degron of MDTPPPE