DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
LRSTLQTME
Uniprot ID:
Q07065
Source protein:
Cytoskeleton-associated protein 4
Source gene:
CKAP4
Class:
DEG_APCC_DBOX_1
Location:
310:318
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8635
ASA_SCORE:
94.9667
COIL:
0.0389
CONS_SCORE:
0.501
DSS_SCORE:
0.3535
HELIX:
0.9614
FCONS_SCORE:
1.0174
RIG_SCORE:
0.7759
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E308K
TCGA-A5-A1OF
UCEC
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.2778
p.E308K
DO42568
UCEC
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.2778
p.E327K
TCGA-AG-A002
READ
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.0833
p.E324D
TCGA-AP-A051
UCEC
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.1667
p.E324D
DO42673
UCEC
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.1667
p.R303G
TCGA-B0-5705
KIRC
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.1389
p.R303G
DO19913
KIRC
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.1389
p.R326C
TCGA-CG-4306
STAD
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.1111
p.R326C
DO38567
STAD
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.1111
p.S302F
TCGA-VQ-A8PT
STAD
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.1111
p.S302F
DO51776
STAD
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.1111
p.L314I
TCGA-XK-AAIW
PRAD
TCGA
LRSTLQTME
DEG_APCC_DBOX_1
0.7174
p.L314I
DO51407
PRAD
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.7174
p.A309P
DO228299
LICA
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.3056
p.A309S
DO50929
LICA
ICGC
LRSTLQTME
DEG_APCC_DBOX_1
0.3056
Drug responses associated with CKAP4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRSTLQTME
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q07065
Cytoskeleton-associated protein 4
DEG_APCC_DBOX_1
310:318
LRSTLQTME
APC,CDC20,FZR1
0.8635
More...