DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_SCF_FBW7_2

Location: 974:980

E3 ligase: FBXW7

DEGRON score: 0.7896

ASA_SCORE: 85.3143

COIL: 0.7024

CONS_SCORE: 0.2931

DSS_SCORE: 0.6384

HELIX: 0.2807

FCONS_SCORE: 0.9292

RIG_SCORE: 0.6428

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P977L	TCGA-AP-A1DK	UCEC	TCGA	LRTPSTE	DEG_SCF_FBW7_2	0.7582
p.P977L	DO42033	UCEC	ICGC	LRTPSTE	DEG_SCF_FBW7_2	0.7582
p.S973Y	TCGA-EO-A22U	UCEC	TCGA	LRTPSTE	DEG_SCF_FBW7_2	0.75
p.S973Y	DO43755	UCEC	ICGC	LRTPSTE	DEG_SCF_FBW7_2	0.75
p.S973Y	SIDM00193	Colorectal Carcinoma	GDSC	LRTPSTE	DEG_SCF_FBW7_2	0.75
p.S973Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.75
p.S973Y	SNU-81	large_intestine	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.75
p.S975I	ACH-001081	Colon/Colorectal Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.7341
p.S975I	HCC2998	large_intestine	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.7341
p.Y979H	HT-144	skin	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.7229
p.S978N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRTPSTE	DEG_SCF_FBW7_2	0.7069
p.S978N	SIDM00785	Acute Myeloid Leukemia	GDSC	LRTPSTE	DEG_SCF_FBW7_2	0.7069
p.S968L	TCGA-55-8204	LUAD	TCGA	LRTPSTE	DEG_SCF_FBW7_2	0.6111
p.S968L	DO45322	LUAD	ICGC	LRTPSTE	DEG_SCF_FBW7_2	0.6111
p.Y967H	TCGA-B5-A3FA	UCEC	TCGA	LRTPSTE	DEG_SCF_FBW7_2	0.5833
p.Y967H	DO52402	UCEC	ICGC	LRTPSTE	DEG_SCF_FBW7_2	0.5833
p.Y967H	HT-144	skin	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.5833
p.Y983H	ACH-000322	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.25
p.Y983H	ACH-002458	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.25
p.Y983H	ACH-002459	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.25
p.Y983H	ACH-002460	Skin Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.25
p.Y983H	HT-144	skin	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.25
p.S971I	HCC2998	large_intestine	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.25
p.V970A	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRTPSTE	DEG_SCF_FBW7_2	0.2222
p.V970A	EN	endometrium	COSMIC	LRTPSTE	DEG_SCF_FBW7_2	0.2222

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Drug responses associated with TJP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRTPSTE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	DEG_SCF_FBW7_2	974:980	LRTPSTE	FBXW7	0.7896	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRTPSTE

Degron related mutations and impact score

Drug responses associated with TJP1 mutations

All proteins holding degron of LRTPSTE