DegronMD

Uniprot ID: Q96L12

Source protein: Calreticulin-3

Source gene: CALR3

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7245

ASA_SCORE: 63.3889

COIL: 0.5718

CONS_SCORE: 0.6329

DSS_SCORE: 0.0024

HELIX: 0.2912

FCONS_SCORE: 1.3441

RIG_SCORE: 0.989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F27C	TCGA-EO-A3AV	UCEC	TCGA	LRVALATVY	DEG_APCC_DBOX_1	0.1944
p.F27C	DO52412	UCEC	ICGC	LRVALATVY	DEG_APCC_DBOX_1	0.1944
p.E25Q	TCGA-Q9-A6FW	ESCA	TCGA	LRVALATVY	DEG_APCC_DBOX_1	0.25
p.G30R	DO233233	GACA	ICGC	LRVALATVY	DEG_APCC_DBOX_1	0.1111
p.V6G	DO233764	GACA	ICGC	LRVALATVY	DEG_APCC_DBOX_1	0.1111
p.C12R	DO227933	PBCA	ICGC	LRVALATVY	DEG_APCC_DBOX_1	0.2778
p.M13V	SIDM01246	Ewing's Sarcoma	GDSC	LRVALATVY	DEG_APCC_DBOX_1	0.3056
p.M13V	SIDM00634	Ewing's Sarcoma	GDSC	LRVALATVY	DEG_APCC_DBOX_1	0.3056
p.M13V	ACH-002160	Bone Cancer	CCLE	LRVALATVY	DEG_APCC_DBOX_1	0.3056
p.M13V	MC-IXC	autonomic_ganglia	COSMIC	LRVALATVY	DEG_APCC_DBOX_1	0.3056
p.A10T	SIDM01559	Melanoma	GDSC	LRVALATVY	DEG_APCC_DBOX_1	0.2222
p.A10T	ACH-000296	Colon/Colorectal Cancer	CCLE	LRVALATVY	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L12	Calreticulin-3	DEG_APCC_DBOX_1	14:22	LRVALATVY	APC,CDC20,FZR1	0.7245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons