DegronMD

Uniprot ID: Q99715

Source protein: Collagen alpha-1

Source gene: COL12A1

Class: LIG_APCC_ABBA_1

Location: 2031:2036

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5556

ASA_SCORE: 63.15

COIL: 0.1058

CONS_SCORE: 0.5759

DSS_SCORE: 0.4666

HELIX: 0.002

FCONS_SCORE: 1.0668

RIG_SCORE: 0.7302

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2046N	TCGA-A2-A0EQ	BRCA	TCGA	LRVFGE	LIG_APCC_ABBA_1	0.0556
p.D2046N	DO4773	BRCA	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.0556
p.R2025H	TCGA-AA-A00N	COAD	TCGA	LRVFGE	LIG_APCC_ABBA_1	0.1667
p.R2025H	DO9876	COAD	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.1667
p.R2025H	DO45299	LIRI	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.1667
p.S2040N	TCGA-AP-A059	UCEC	TCGA	LRVFGE	LIG_APCC_ABBA_1	0.2222
p.S2040N	DO41361	UCEC	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.2222
p.G2027E	TCGA-CG-4306	STAD	TCGA	LRVFGE	LIG_APCC_ABBA_1	0.2222
p.G2027E	DO38567	STAD	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.2222
p.W2045C	TCGA-EE-A183	SKCM	TCGA	LRVFGE	LIG_APCC_ABBA_1	0.0833
p.W2045C	DO37715	SKCM	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.0833
p.T2022M	TCGA-VQ-A8PB	STAD	TCGA	LRVFGE	LIG_APCC_ABBA_1	0.0833
p.T2022M	DO6507	CLLE	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.0833
p.T2022M	DO231708	LINC	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.0833
p.T2022M	DO51766	STAD	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.0833
p.T2037K	DO228974	LICA	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.3056
p.G2035C	DO50843	LICA	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.6489
p.A2044G	DO228325	MALY	ICGC	LRVFGE	LIG_APCC_ABBA_1	0.1111
p.R2021Q	SIDM00319	Melanoma	GDSC	LRVFGE	LIG_APCC_ABBA_1	0.0556
p.R2021Q	SIDM00654	Small Cell Lung Carcinoma	GDSC	LRVFGE	LIG_APCC_ABBA_1	0.0556
p.R2021Q	SIDM00210	Ovarian Carcinoma	GDSC	LRVFGE	LIG_APCC_ABBA_1	0.0556
p.S2026N	SIDM00660	Colorectal Carcinoma	GDSC	LRVFGE	LIG_APCC_ABBA_1	0.1944
p.S2026N	ACH-000985	Colon/Colorectal Cancer	CCLE	LRVFGE	LIG_APCC_ABBA_1	0.1944
p.S2026N	LS-411N	large_intestine	COSMIC	LRVFGE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99715	Collagen alpha-1	LIG_APCC_ABBA_1	2031:2036	LRVFGE	APC,CDC20,FZR1	0.5556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons