DegronMD

Uniprot ID: O15484

Source protein: Calpain-5

Source gene: CAPN5

Class: LIG_APCC_ABBA_1

Location: 485:490

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 23.9667

COIL: 0.1873

CONS_SCORE: 0.5705

DSS_SCORE: 0.2177

HELIX: 0.0005

FCONS_SCORE: 1.5509

RIG_SCORE: 0.9008

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E476D	TCGA-13-0760	OV	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.E476D	DO28541	OV	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.G481D	TCGA-A5-A1OF	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.2222
p.G481D	TCGA-AG-3592	READ	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.2222
p.G481D	DO37308	READ	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.2222
p.G481D	DO42568	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.2222
p.R496Q	TCGA-A6-6781	COAD	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.1667
p.R496Q	DO8447	COAD	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.1667
p.R499C	TCGA-AP-A1DO	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.R499C	DO218910	SKCA	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.R499C	DO43250	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.R499H	TCGA-B5-A11Y	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.R499H	TCGA-EO-A22R	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.R499H	DO40889	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.R499H	DO42713	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.0833
p.D490N	TCGA-CV-A468	HNSC	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.6932
p.D490N	DO52070	HNSC	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.6932
p.E497G	TCGA-DF-A2KU	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.1389
p.E497G	DO223286	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.1389
p.P492S	TCGA-ER-A19N	SKCM	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.2778
p.P492S	DO37452	SKCM	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.2778
p.P492S	SIDM00003	Melanoma	GDSC	LRVFTD	LIG_APCC_ABBA_1	0.2778
p.P492S	M14	skin	COSMIC	LRVFTD	LIG_APCC_ABBA_1	0.2778
p.R496W	TCGA-HU-A4GX	STAD	TCGA	LRVFTD	LIG_APCC_ABBA_1	0.1667
p.R496W	DO47757	STAD	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.1667
p.R496L	DO230346	COCA	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.1667
p.V487F	DO229028	LICA	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.7068
p.G478S	DO50834	LIRI	ICGC	LRVFTD	LIG_APCC_ABBA_1	0.1389
p.N494S	SIDM00625	Other Sarcomas	GDSC	LRVFTD	LIG_APCC_ABBA_1	0.2222
p.N494S	MES-SA	soft_tissue	COSMIC	LRVFTD	LIG_APCC_ABBA_1	0.2222
p.R500L	ACH-000781	Lung Cancer	CCLE	LRVFTD	LIG_APCC_ABBA_1	0.0556
p.R500L	NCI-H2023	lung	COSMIC	LRVFTD	LIG_APCC_ABBA_1	0.0556
p.K485E	IHH-4	thyroid	COSMIC	LRVFTD	LIG_APCC_ABBA_1	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRVFTD

Degron related mutations and impact score

Drug responses associated with CAPN5 mutations

All proteins holding degron of LRVFTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15484	Calpain-5	LIG_APCC_ABBA_1	485:490	LRVFTD	APC,CDC20,FZR1	0.5198	More...