DegronMD - O15484(CAPN5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E476D	TCGA-13-0760	OV	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.E476D	DO28541	OV	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.G481D	TCGA-A5-A1OF	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2222
p.G481D	TCGA-AG-3592	READ	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2222
p.G481D	DO37308	READ	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2222
p.G481D	DO42568	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2222
p.R496Q	TCGA-A6-6781	COAD	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1667
p.R496Q	DO8447	COAD	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1667
p.R18W	TCGA-AH-6644	READ	TCGA	VKPYED	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1111
p.R18W	DO37237	READ	ICGC	VKPYED	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1111
p.R18W	SIDM00493	Other Solid Cancers	GDSC	VKPYED	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1111
p.R499C	TCGA-AP-A1DO	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.R499C	DO218910	SKCA	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.R499C	DO43250	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.R499H	TCGA-B5-A11Y	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.R499H	TCGA-EO-A22R	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.R499H	DO40889	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.R499H	DO42713	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0833
p.D490N	TCGA-CV-A468	HNSC	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation altering degron motif	0.6932
p.D490N	DO52070	HNSC	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation altering degron motif	0.6932
p.E497G	TCGA-DF-A2KU	UCEC	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1389
p.E497G	DO223286	UCEC	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1389
p.P492S	TCGA-ER-A19N	SKCM	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2778
p.P492S	DO37452	SKCM	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2778
p.P492S	SIDM00003	Melanoma	GDSC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2778
p.P492S	M14	skin	COSMIC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2778
p.S14L	TCGA-FD-A3SO	BLCA	TCGA	VKPYED	LIG_APCC_ABBA_1	5:10	Mutation blocking phosphorylation signal	0.6667
p.S14L	DO569	BLCA	ICGC	VKPYED	LIG_APCC_ABBA_1	5:10	Mutation blocking phosphorylation signal	0.6667
p.R496W	TCGA-HU-A4GX	STAD	TCGA	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1667
p.R496W	DO47757	STAD	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1667
p.R496L	DO230346	COCA	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1667
p.V487F	DO229028	LICA	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation altering degron motif	0.7068
p.G478S	DO50834	LIRI	ICGC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.1389
p.N494S	SIDM00625	Other Sarcomas	GDSC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2222
p.N494S	MES-SA	soft tissue	COSMIC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.2222
p.R18Q	SIDM00377	Other Sarcomas	GDSC	VKPYED	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1111
p.R500L	ACH-000781	Lung Cancer	CCLE	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0556
p.R500L	NCI-H2023	lung	COSMIC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation rewiring degron network	0.0556
p.K485E	IHH-4	thyroid	COSMIC	LRVFTD	LIG_APCC_ABBA_1	485:490	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAPN5

UniProt ID: O15484

Entrez ID: 726

Protein name: Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAPN5 in