DegronMD

Uniprot ID: O15484

Source protein: Calpain-5

Source gene: CAPN5

Class: LIG_APCC_ABBA_1

Location: 5:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7924

ASA_SCORE: 91.0167

COIL: 0.8893

CONS_SCORE: 0.3787

DSS_SCORE: 0.3689

HELIX: 0.0925

FCONS_SCORE: 0.9862

RIG_SCORE: 0.802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R18W	TCGA-AH-6644	READ	TCGA	VKPYED	LIG_APCC_ABBA_1	0.1111
p.R18W	DO37237	READ	ICGC	VKPYED	LIG_APCC_ABBA_1	0.1111
p.R18W	SIDM00493	Other Solid Cancers	GDSC	VKPYED	LIG_APCC_ABBA_1	0.1111
p.S14L	TCGA-FD-A3SO	BLCA	TCGA	VKPYED	LIG_APCC_ABBA_1	0.6667
p.S14L	DO569	BLCA	ICGC	VKPYED	LIG_APCC_ABBA_1	0.6667
p.R18Q	SIDM00377	Other Sarcomas	GDSC	VKPYED	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15484	Calpain-5	LIG_APCC_ABBA_1	5:10	VKPYED	APC,CDC20,FZR1	0.7924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons