DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRVPLAPIT
Uniprot ID:
P31350
Source protein:
Ribonucleoside-diphosphate reductase subunit M2
Source gene:
RRM2
Class:
DEG_APCC_DBOX_1
Location:
4:12
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9914
ASA_SCORE:
94.3222
COIL:
0.9506
CONS_SCORE:
0.2238
DSS_SCORE:
0.4482
HELIX:
0.0243
FCONS_SCORE:
0.9836
RIG_SCORE:
0.7727
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RRM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRVPLAPIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P31350
Ribonucleoside-diphosphate reductase subunit M2
DEG_APCC_DBOX_1
4:12
LRVPLAPIT
APC,CDC20,FZR1
0.9914
More...