DegronMD

Uniprot ID: Q9BXM0

Source protein: Periaxin

Source gene: PRX

Class: DEG_APCC_DBOX_1

Location: 1433:1441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9351

ASA_SCORE: 58.7

COIL: 0.4712

CONS_SCORE: 0.8558

DSS_SCORE: 0.5735

HELIX: 0.0154

FCONS_SCORE: 1.0011

RIG_SCORE: 0.7092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1450L	TCGA-37-A5EL	LUSC	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	0.0833
p.P1450L	DO223718	LUSC	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.0833
p.R1434W	TCGA-AM-5821	COAD	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	0.8634
p.R1434W	DO8240	COAD	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.8634
p.R1434Q	TCGA-AX-A3G9	UCEC	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	0.7329
p.R1434Q	DO41241	UCEC	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.7329
p.R1436W	TCGA-BR-8285	STAD	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	0.7523
p.R1436W	DO38479	STAD	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.7523
p.P1450Q	TCGA-D6-8568	HNSC	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	0.0833
p.P1450Q	DO14388	HNSC	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.0833
p.P1438S	TCGA-DK-A6AW	BLCA	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	0.5641
p.P1438S	DO48566	BLCA	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.5641
p.G1424W	DO46374	OV	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	0.0833
p.R1436Q	SIDM00078	Oral Cavity Carcinoma	GDSC	LRVRLPSVG	DEG_APCC_DBOX_1	0.6218
p.R1436Q	ACH-000228	Head and Neck Cancer	CCLE	LRVRLPSVG	DEG_APCC_DBOX_1	0.6218
p.R1436Q	BICR31	upper_aerodigestive_tract	COSMIC	LRVRLPSVG	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXM0	Periaxin	DEG_APCC_DBOX_1	1433:1441	LRVRLPSVG	APC,CDC20,FZR1	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons