DegronMD

Uniprot ID: Q5VSG8

Source protein: Glycoprotein endo-alpha-1,2-mannosidase-like protein

Source gene: MANEAL

Class: LIG_APCC_ABBA_1

Location: 99:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7812

ASA_SCORE: 71.9

COIL: 0.7357

CONS_SCORE: 0.3566

DSS_SCORE: 0.1581

HELIX: 0.0653

FCONS_SCORE: 0.7357

RIG_SCORE: 0.808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H106Y	TCGA-AZ-6598	COAD	TCGA	LRVYSD	LIG_APCC_ABBA_1	0.2778
p.H106Y	DO10276	COAD	ICGC	LRVYSD	LIG_APCC_ABBA_1	0.2778
p.G114W	TCGA-CQ-6223	HNSC	TCGA	LRVYSD	LIG_APCC_ABBA_1	0.0556
p.G114W	DO15318	HNSC	ICGC	LRVYSD	LIG_APCC_ABBA_1	0.0556
p.Y110C	DO231515	LINC	ICGC	LRVYSD	LIG_APCC_ABBA_1	0.1667
p.S111L	DO219871	SKCA	ICGC	LRVYSD	LIG_APCC_ABBA_1	0.1389
p.V101I	SIDM00217	Colorectal Carcinoma	GDSC	LRVYSD	LIG_APCC_ABBA_1	0.5965
p.G94R	BHY	upper_aerodigestive_tract	COSMIC	LRVYSD	LIG_APCC_ABBA_1	0.1944
p.T101M	SK-UT-1	soft_tissue	COSMIC	LRVYSD	LIG_APCC_ABBA_1	0.7423
p.A95T	SNU-1040	large_intestine	COSMIC	LRVYSD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VSG8	Glycoprotein endo-alpha-1,2-mannosidase-like protein	LIG_APCC_ABBA_1	99:104	LRVYSD	APC,CDC20,FZR1	0.7812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons