DegronMD - Q5VSG8(MANEAL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K136N	TCGA-A3-3308	KIRC	TCGA	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.2778
p.K136N	DO16110	KIRC	ICGC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.2778
p.H106Y	TCGA-AZ-6598	COAD	TCGA	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.H106Y	DO10276	COAD	ICGC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2778
p.V130M	TCGA-CK-4951	COAD	TCGA	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation altering degron motif	0.6097
p.V130M	DO10582	COAD	ICGC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation altering degron motif	0.6097
p.G114W	TCGA-CQ-6223	HNSC	TCGA	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0556
p.G114W	DO15318	HNSC	ICGC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0556
p.A139V	TCGA-EE-A2MR	SKCM	TCGA	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.1944
p.A139V	DO37819	SKCM	ICGC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.1944
p.M129I	TCGA-P6-A5OG	ACC	TCGA	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation altering degron motif	0.6507
p.Y110C	DO231515	LINC	ICGC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.S111L	DO219871	SKCA	ICGC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1389
p.P131L	DO229144	THCA	ICGC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation altering degron motif	0.6471
p.G120C	DO229250	THCA	ICGC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.0833
p.P135L	SIDM00970	Bladder Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	SIDM00618	Hepatocellular Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	SIDM00217	Colorectal Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	SIDM00167	Head and Neck Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	SIDM00169	Head and Neck Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	SNU-1040	large intestine	COSMIC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	JHH-1	liver	COSMIC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.P135L	DSH1	urinary tract	COSMIC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.3056
p.V101I	SIDM00217	Colorectal Carcinoma	GDSC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5965
p.Y141S	ACH-002312	Gallbladder Cancer	CCLE	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.1389
p.G94R	BHY	upper aerodigestive tract	COSMIC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1944
p.T101M	SK-UT-1	soft tissue	COSMIC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.7423
p.C125S	COR-L321	NS	COSMIC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.2222
p.A95T	SNU-1040	large intestine	COSMIC	LRVYSD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.2222
p.A123T	SNU-1040	large intestine	COSMIC	MVPHWD	LIG_APCC_ABBA_1	129:134	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MANEAL

UniProt ID: Q5VSG8

Entrez ID: 149175

Protein name: Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC 3.2.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MANEAL in