DegronMD

Uniprot ID: Q5VSG8

Source protein: Glycoprotein endo-alpha-1,2-mannosidase-like protein

Source gene: MANEAL

Class: LIG_APCC_ABBA_1

Location: 129:134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5321

ASA_SCORE: 50.1333

COIL: 0.8195

CONS_SCORE: 0.436

DSS_SCORE: 0.1287

HELIX: 0.1138

FCONS_SCORE: 0.985

RIG_SCORE: 0.8034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K136N	TCGA-A3-3308	KIRC	TCGA	MVPHWD	LIG_APCC_ABBA_1	0.2778
p.K136N	DO16110	KIRC	ICGC	MVPHWD	LIG_APCC_ABBA_1	0.2778
p.V130M	TCGA-CK-4951	COAD	TCGA	MVPHWD	LIG_APCC_ABBA_1	0.6097
p.V130M	DO10582	COAD	ICGC	MVPHWD	LIG_APCC_ABBA_1	0.6097
p.A139V	TCGA-EE-A2MR	SKCM	TCGA	MVPHWD	LIG_APCC_ABBA_1	0.1944
p.A139V	DO37819	SKCM	ICGC	MVPHWD	LIG_APCC_ABBA_1	0.1944
p.M129I	TCGA-P6-A5OG	ACC	TCGA	MVPHWD	LIG_APCC_ABBA_1	0.6507
p.P131L	DO229144	THCA	ICGC	MVPHWD	LIG_APCC_ABBA_1	0.6471
p.G120C	DO229250	THCA	ICGC	MVPHWD	LIG_APCC_ABBA_1	0.0833
p.P135L	SIDM00970	Bladder Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	SIDM00618	Hepatocellular Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	SIDM00217	Colorectal Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	SIDM00167	Head and Neck Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	SIDM00169	Head and Neck Carcinoma	GDSC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	SNU-1040	large_intestine	COSMIC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	JHH-1	liver	COSMIC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.P135L	DSH1	urinary_tract	COSMIC	MVPHWD	LIG_APCC_ABBA_1	0.3056
p.Y141S	ACH-002312	Gallbladder Cancer	CCLE	MVPHWD	LIG_APCC_ABBA_1	0.1389
p.C125S	COR-L321	NS	COSMIC	MVPHWD	LIG_APCC_ABBA_1	0.2222
p.A123T	SNU-1040	large_intestine	COSMIC	MVPHWD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VSG8	Glycoprotein endo-alpha-1,2-mannosidase-like protein	LIG_APCC_ABBA_1	129:134	MVPHWD	APC,CDC20,FZR1	0.5321	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons