DegronMD

Uniprot ID: O75691

Source protein: Small subunit processome component 20 homolog

Source gene: UTP20

Class: DEG_APCC_DBOX_1

Location: 721:729

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.567

ASA_SCORE: 20.2889

COIL: 0.1581

CONS_SCORE: 0.4577

DSS_SCORE: 0.0122

HELIX: 0.8251

FCONS_SCORE: 1.2747

RIG_SCORE: 0.9485

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P712A	TCGA-66-2765	LUSC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.0833
p.P712A	DO26761	LUSC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.0833
p.P720L	TCGA-A5-A2K3	UCEC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.P720L	DO43899	UCEC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.P720L	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.P720L	VMRC-LCD	lung	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.R722H	TCGA-AX-A064	UCEC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8244
p.R722H	DO52485	COCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8244
p.R722H	DO43073	UCEC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8244
p.R722C	TCGA-CA-6717	COAD	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	TCGA-D3-A2JH	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	TCGA-DA-A3F8	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	DO8264	COAD	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	DO47263	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	DO37418	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	SIDM00118	Colorectal Carcinoma	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	ACH-001081	Colon/Colorectal Cancer	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	HCC2998	large_intestine	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.P738S	TCGA-D9-A3Z4	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.0833
p.P738S	DO37623	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.0833
p.G726V	DO229029	LICA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.6421
p.M727I	DO229029	LICA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.6507
p.M727V	DO35083	PACA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.6097
p.S733N	DO36095	PBCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733N	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733N	ACH-000922	Leukemia	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733N	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733R	DO229268	THCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.F732L	ACH-000779	Lung Cancer	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRYLLGMLY

Degron related mutations and impact score

Drug responses associated with UTP20 mutations

All proteins holding degron of LRYLLGMLY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75691	Small subunit processome component 20 homolog	DEG_APCC_DBOX_1	721:729	LRYLLGMLY	APC,CDC20,FZR1	0.567	More...