DegronMD

Uniprot ID: O75691

Source protein: Small subunit processome component 20 homolog

Source gene: UTP20

Class: DEG_APCC_DBOX_1

Location: 721:729

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.567

ASA_SCORE: 20.2889

COIL: 0.1581

CONS_SCORE: 0.4577

DSS_SCORE: 0.0122

HELIX: 0.8251

FCONS_SCORE: 1.2747

RIG_SCORE: 0.9485

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R722C	TCGA-CA-6717	COAD	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	TCGA-D3-A2JH	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	TCGA-DA-A3F8	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	DO8264	COAD	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	DO47263	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	DO37418	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	SIDM00118	Colorectal Carcinoma	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	ACH-001081	Colon/Colorectal Cancer	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722C	HCC2998	large_intestine	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8301
p.R722H	TCGA-AX-A064	UCEC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.8244
p.R722H	DO52485	COCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8244
p.R722H	DO43073	UCEC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.8244
p.M727I	DO229029	LICA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.6507
p.G726V	DO229029	LICA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.6421
p.M727V	DO35083	PACA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.6097
p.P720L	TCGA-A5-A2K3	UCEC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.P720L	DO43899	UCEC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.P720L	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.P720L	VMRC-LCD	lung	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	0.3056
p.F732L	ACH-000779	Lung Cancer	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	0.25
p.S733N	DO36095	PBCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733N	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733N	ACH-000922	Leukemia	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733N	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222
p.S733R	DO229268	THCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	0.2222

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Drug responses associated with UTP20 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRYLLGMLY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75691	Small subunit processome component 20 homolog	DEG_APCC_DBOX_1	721:729	LRYLLGMLY	APC,CDC20,FZR1	0.567	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRYLLGMLY

Degron related mutations and impact score

Drug responses associated with UTP20 mutations

All proteins holding degron of LRYLLGMLY