DegronMD - O75691(UTP20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1759K	TCGA-09-2044	OV	TCGA	DSGGTS	DEG_SCF_TRCP1_1	1746:1751	Mutation rewiring degron network	0.1111
p.T1759K	DO28923	OV	ICGC	DSGGTS	DEG_SCF_TRCP1_1	1746:1751	Mutation rewiring degron network	0.1111
p.K1753E	TCGA-43-8118	LUSC	TCGA	DSGGTS	DEG_SCF_TRCP1_1	1746:1751	Mutation rewiring degron network	0.2778
p.K1753E	DO45471	LUSC	ICGC	DSGGTS	DEG_SCF_TRCP1_1	1746:1751	Mutation rewiring degron network	0.2778
p.P712A	TCGA-66-2765	LUSC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.0833
p.P712A	DO26761	LUSC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.0833
p.P720L	TCGA-A5-A2K3	UCEC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.3056
p.P720L	DO43899	UCEC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.3056
p.P720L	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.3056
p.P720L	VMRC-LCD	lung	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.3056
p.R722H	TCGA-AX-A064	UCEC	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8244
p.R722H	DO52485	COCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8244
p.R722H	DO43073	UCEC	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8244
p.R722C	TCGA-CA-6717	COAD	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	TCGA-D3-A2JH	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	TCGA-DA-A3F8	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	DO8264	COAD	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	DO47263	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	DO37418	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	SIDM00118	Colorectal Carcinoma	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	ACH-001081	Colon/Colorectal Cancer	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.R722C	HCC2998	large intestine	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.8301
p.P738S	TCGA-D9-A3Z4	SKCM	TCGA	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.0833
p.P738S	DO37623	SKCM	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.0833
p.G726V	DO229029	LICA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.6421
p.M727I	DO229029	LICA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.6507
p.D1746Y	DO32896	PACA	ICGC	DSGGTS	DEG_SCF_TRCP1_1	1746:1751	Mutation altering degron motif	0.7325
p.M727V	DO35083	PACA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation altering degron motif	0.6097
p.S733N	DO36095	PBCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.2222
p.S733N	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.2222
p.S733N	ACH-000922	Leukemia	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.2222
p.S733N	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.2222
p.S733R	DO229268	THCA	ICGC	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.2222
p.F732L	ACH-000779	Lung Cancer	CCLE	LRYLLGMLY	DEG_APCC_DBOX_1	721:729	Mutation rewiring degron network	0.25

Kaplan plot for UTP20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UTP20

UniProt ID: O75691

Entrez ID: 27340

Protein name: Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UTP20 in