DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1769:1776

E3 ligase: FBXW7

DEGRON score: 0.6269

ASA_SCORE: 95.1625

COIL: 0.9149

CONS_SCORE: 0.5236

DSS_SCORE: 0.5953

HELIX: 0.0128

FCONS_SCORE: 1

RIG_SCORE: 0.6874

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1774T	TCGA-78-7166	LUAD	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.5966
p.I1774T	DO25629	LUAD	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.5966
p.A1771S	TCGA-95-A4VN	LUAD	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.6477
p.A1771S	DO51199	LUAD	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.6477
p.T1781A	TCGA-AB-2808	LAML	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.1944
p.T1781A	DO21487	LAML	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.1944
p.T1781I	TCGA-AB-2808	LAML	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.1944
p.T1781I	DO21487	LAML	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.1944
p.D1775G	TCGA-AP-A0LM	UCEC	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.6087
p.D1775G	DO43306	UCEC	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.6087
p.S1777N	TCGA-C5-A7X5	CESC	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.3056
p.S1777N	DO49894	CESC	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.3056
p.P1773H	TCGA-E6-A1LX	UCEC	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.7694
p.P1773H	DO41020	UCEC	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.7694
p.I1774V	TCGA-EM-A22Q	THCA	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.5965
p.I1774V	DO40141	THCA	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.5965
p.E1765D	TCGA-HT-8106	LGG	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.2222
p.E1765D	DO22711	LGG	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.2222
p.E1765K	TCGA-PJ-A8JU	KIRP	TCGA	LSATPIDT	DEG_SCF_FBW7_1	0.2222
p.E1765K	DO48523	KIRP	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.2222
p.A1771T	DO229052	LICA	ICGC	LSATPIDT	DEG_SCF_FBW7_1	0.6028
p.T1782I	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.1667
p.T1782I	ACH-000611	Lymphoma	CCLE	LSATPIDT	DEG_SCF_FBW7_1	0.1667
p.A1786G	SIDM00496	Thyroid Gland Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM01005	Acute Myeloid Leukemia	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM00002	Neuroblastoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM00530	Esophageal Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM00585	Hepatocellular Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM00587	Biliary Tract Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM00324	Neuroblastoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	SIDM01660	Kidney Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	TE-8	oesophagus	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	HuH-7	liver	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	HuCCT1	biliary_tract	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	KYSE-70	oesophagus	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	NBsusSR	autonomic_ganglia	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	KYAE-1	oesophagus	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	HTC-C3	thyroid	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.A1786G	TGW	autonomic_ganglia	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.0556
p.T1778N	SIDM01099	Neuroblastoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.2778
p.S1767N	SIDM00963	Breast Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.2778
p.S1783Y	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.1389
p.S1783Y	ACH-000596	Lung Cancer	CCLE	LSATPIDT	DEG_SCF_FBW7_1	0.1389
p.S1783Y	LCLC-97TM1	lung	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.1389
p.S1767I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LSATPIDT	DEG_SCF_FBW7_1	0.2778
p.S1767I	ACH-000672	Lung Cancer	CCLE	LSATPIDT	DEG_SCF_FBW7_1	0.2778
p.S1767I	IA-LM	lung	COSMIC	LSATPIDT	DEG_SCF_FBW7_1	0.2778
p.S1777G	ACH-001613	Leukemia	CCLE	LSATPIDT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSATPIDT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSATPIDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1769:1776	LSATPIDT	FBXW7	0.6269	More...