DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LSATPTEE
Uniprot ID:
Q765P7
Source protein:
Protein MTSS 2
Source gene:
MTSS2
Class:
DEG_SCF_FBW7_2
Location:
699:706
E3 ligase:
FBXW7
DEGRON score:
0.9922
ASA_SCORE:
102.15
COIL:
0.9501
CONS_SCORE:
0.4951
DSS_SCORE:
0.7515
HELIX:
0.0247
FCONS_SCORE:
1.1123
RIG_SCORE:
0.6244
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A714T
SIDM00331
B-Lymphoblastic Leukemia
GDSC
LSATPTEE
DEG_SCF_FBW7_2
0.1111
Drug responses associated with MTSS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSATPTEE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q765P7
Protein MTSS 2
DEG_SCF_FBW7_2
699:706
LSATPTEE
FBXW7
0.9922
More...