DegronMD

Uniprot ID: Q17R60

Source protein: Interphotoreceptor matrix proteoglycan 1

Source gene: IMPG1

Class: DEG_SCF_FBW7_1

Location: 524:531

E3 ligase: FBXW7

DEGRON score: 0.952

ASA_SCORE: 74.3

COIL: 0.8874

CONS_SCORE: 0.5299

DSS_SCORE: 0.6647

HELIX: 0.0535

FCONS_SCORE: 1.0056

RIG_SCORE: 0.6315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V540F	TCGA-43-2576	LUSC	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.0833
p.V540F	DO27005	LUSC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.0833
p.P528T	TCGA-55-8301	LUAD	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.7031
p.P528T	DO24682	LUAD	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.7031
p.S537R	TCGA-63-7020	LUSC	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.S537R	DO27596	LUSC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.S525F	TCGA-A4-7287	KIRP	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.6871
p.S525F	DO20825	KIRP	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.6871
p.E532K	TCGA-DS-A0VM	CESC	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.3056
p.E532K	DO6258	CESC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.3056
p.P528S	TCGA-ER-A19G	SKCM	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.6752
p.P528S	DO47284	SKCM	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.6752
p.L519I	TCGA-MP-A4SV	LUAD	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	0.1944
p.L519I	DO231821	LINC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1944
p.L519I	DO45339	LUAD	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1944
p.H518D	DO229010	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.H518D	DO229013	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.H518D	DO229016	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.H518D	DO229005	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.H518D	DO229028	LICA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1667
p.T527N	DO229034	LICA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.7055
p.D514N	DO232852	NACA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.0556
p.E538K	DO229453	SKCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	0.1389
p.Y539C	SIDM01291	Esophageal Carcinoma	GDSC	LSDTPAPS	DEG_SCF_FBW7_1	0.1111
p.N538T	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	LSDTPAPS	DEG_SCF_FBW7_1	0.1389
p.E519K	KYSE-150	oesophagus	COSMIC	LSDTPAPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R60	Interphotoreceptor matrix proteoglycan 1	DEG_SCF_FBW7_1	524:531	LSDTPAPS	FBXW7	0.952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons