DegronMD - Q17R60(IMPG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A190V	TCGA-06-6700	GBM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1111
p.A190V	DO12850	GBM	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1111
p.V540F	TCGA-43-2576	LUSC	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.0833
p.V540F	DO27005	LUSC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.0833
p.P528T	TCGA-55-8301	LUAD	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.7031
p.P528T	DO24682	LUAD	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.7031
p.S537R	TCGA-63-7020	LUSC	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.S537R	DO27596	LUSC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.S525F	TCGA-A4-7287	KIRP	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.6871
p.S525F	DO20825	KIRP	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.6871
p.L210F	TCGA-A5-A2K5	UCEC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.L210F	DO41379	UCEC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.V192I	TCGA-AA-3489	COAD	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.V192I	DO10702	COAD	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.G195A	TCGA-AF-4110	READ	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.25
p.G195A	DO37380	READ	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.25
p.D188Y	TCGA-D3-A2JD	SKCM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.0556
p.E532K	TCGA-DS-A0VM	CESC	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.3056
p.E532K	DO6258	CESC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.3056
p.L210I	TCGA-EO-A22X	UCEC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.L210I	TCGA-FI-A2D5	UCEC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.L210I	DO43907	UCEC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.L210I	DO41331	UCEC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1667
p.P528S	TCGA-ER-A19G	SKCM	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.6752
p.P528S	DO47284	SKCM	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.6752
p.E208K	TCGA-ER-A3PL	SKCM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2222
p.E208K	DO231016	LUSC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2222
p.E208K	DO37495	SKCM	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2222
p.G195W	TCGA-FS-A1ZG	SKCM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.25
p.G195W	DO37523	SKCM	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.25
p.P198S	TCGA-G5-6641	READ	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation altering degron motif	0.6752
p.P198S	DO36909	READ	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation altering degron motif	0.6752
p.L194I	TCGA-HP-A5MZ	LIHC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2222
p.L194I	DO229026	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2222
p.L194I	DO49695	LIHC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2222
p.L519I	TCGA-MP-A4SV	LUAD	TCGA	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1944
p.L519I	DO231821	LINC	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1944
p.L519I	DO45339	LUAD	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1944
p.P196S	TCGA-YF-AA3M	BLCA	TCGA	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2778
p.P196S	DO51952	BLCA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2778
p.H518D	DO229010	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.H518D	DO229013	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.H518D	DO229016	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.H518D	DO229005	COCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.H518D	DO229028	LICA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1667
p.D203E	DO228985	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation altering degron motif	0.5647
p.T213K	DO229031	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation blocking phosphorylation signal	0.5278
p.T527N	DO229034	LICA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation altering degron motif	0.7055
p.L206I	DO229035	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.2778
p.D514N	DO232852	NACA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.0556
p.E538K	DO229453	SKCA	ICGC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1389
p.A190S	DO229264	THCA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1111
p.Y539C	SIDM01291	Esophageal Carcinoma	GDSC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1111
p.D211N	SIDM01088	Endometrial Carcinoma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.D211H	SIDM00793	Burkitt's Lymphoma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.D211H	ACH-002236	Lymphoma	CCLE	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.D211H	EB-3	haematopoietic and lymphoid tissue	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.N191K	SIDM00312	Plasma Cell Myeloma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.N191K	ACH-000183	Myeloma	CCLE	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.N191K	L-363	haematopoietic and lymphoid tissue	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.N191S	SIDM01372	Pancreatic Carcinoma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1389
p.P212Q	NCI-H661	lung	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1111
p.N538T	BV-173	haematopoietic and lymphoid tissue	COSMIC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1389
p.L190I	MDA-MB-415	breast	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	198:204	Mutation rewiring degron network	0.1111
p.E519K	KYSE-150	oesophagus	COSMIC	LSDTPAPS	DEG_SCF_FBW7_1	524:531	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IMPG1

UniProt ID: Q17R60

Entrez ID: 3617

Protein name: Interphotoreceptor matrix proteoglycan 1 (Interphotoreceptor matrix proteoglycan of 150 kDa) (IPM-150) (Sialoprotein associated with cones and rods)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IMPG1 in