DegronMD

Uniprot ID: Q17R60

Source protein: Interphotoreceptor matrix proteoglycan 1

Source gene: IMPG1

Class: DEG_SCF_FBW7_1

Location: 198:204

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 74.3714

COIL: 0.8284

CONS_SCORE: 0.5677

DSS_SCORE: 0.36

HELIX: 0.1204

FCONS_SCORE: 1.1657

RIG_SCORE: 0.7882

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A190V	TCGA-06-6700	GBM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.1111
p.A190V	DO12850	GBM	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.1111
p.L210F	TCGA-A5-A2K5	UCEC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.L210F	DO41379	UCEC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.V192I	TCGA-AA-3489	COAD	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.V192I	DO10702	COAD	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.G195A	TCGA-AF-4110	READ	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.25
p.G195A	DO37380	READ	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.25
p.D188Y	TCGA-D3-A2JD	SKCM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.0556
p.L210I	TCGA-EO-A22X	UCEC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.L210I	TCGA-FI-A2D5	UCEC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.L210I	DO43907	UCEC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.L210I	DO41331	UCEC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.1667
p.E208K	TCGA-ER-A3PL	SKCM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.2222
p.E208K	DO231016	LUSC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.2222
p.E208K	DO37495	SKCM	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.2222
p.G195W	TCGA-FS-A1ZG	SKCM	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.25
p.G195W	DO37523	SKCM	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.25
p.P198S	TCGA-G5-6641	READ	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.6752
p.P198S	DO36909	READ	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.6752
p.L194I	TCGA-HP-A5MZ	LIHC	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.2222
p.L194I	DO229026	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.2222
p.L194I	DO49695	LIHC	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.2222
p.P196S	TCGA-YF-AA3M	BLCA	TCGA	PLTPDDT	DEG_SCF_FBW7_1	0.2778
p.P196S	DO51952	BLCA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.2778
p.D203E	DO228985	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.5647
p.T213K	DO229031	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.5278
p.L206I	DO229035	LICA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.2778
p.A190S	DO229264	THCA	ICGC	PLTPDDT	DEG_SCF_FBW7_1	0.1111
p.D211N	SIDM01088	Endometrial Carcinoma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.D211H	SIDM00793	Burkitt's Lymphoma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.D211H	ACH-002236	Lymphoma	CCLE	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.D211H	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.N191K	SIDM00312	Plasma Cell Myeloma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.N191K	ACH-000183	Myeloma	CCLE	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.N191K	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.N191S	SIDM01372	Pancreatic Carcinoma	GDSC	PLTPDDT	DEG_SCF_FBW7_1	0.1389
p.P212Q	NCI-H661	lung	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	0.1111
p.L190I	MDA-MB-415	breast	COSMIC	PLTPDDT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPDDT

Degron related mutations and impact score

Drug responses associated with IMPG1 mutations

All proteins holding degron of PLTPDDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R60	Interphotoreceptor matrix proteoglycan 1	DEG_SCF_FBW7_1	198:204	PLTPDDT	FBXW7	0.9946	More...