DegronMD

Uniprot ID: Q03692

Source protein: Collagen alpha-1

Source gene: COL10A1

Class: DEG_SCF_FBW7_1

Location: 534:541

E3 ligase: FBXW7

DEGRON score: 0.9877

ASA_SCORE: 66.7125

COIL: 0.9053

CONS_SCORE: 0.398

DSS_SCORE: 0.4865

HELIX: 0.0189

FCONS_SCORE: 0.8493

RIG_SCORE: 0.6966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P538S	TCGA-AJ-A3BH	UCEC	TCGA	LSGTPLVS	DEG_SCF_FBW7_1	0.6752
p.P538S	DO41638	UCEC	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.6752
p.G545R	DO230334	COCA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229010	COCA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229016	COCA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229003	COCA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229005	COCA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229473	LAML	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229505	LAML	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO230659	LAML	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO231140	LAML	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO229047	LICA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.G545R	DO230990	LUSC	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2222
p.F525S	DO227987	COCA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.0833
p.N543K	DO229034	LICA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.2778
p.P550L	DO229050	LICA	ICGC	LSGTPLVS	DEG_SCF_FBW7_1	0.0833
p.S533R	SIDM00313	Hodgkin's Lymphoma	GDSC	LSGTPLVS	DEG_SCF_FBW7_1	0.3056
p.S533R	ACH-000702	Lymphoma	CCLE	LSGTPLVS	DEG_SCF_FBW7_1	0.3056
p.S533R	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	LSGTPLVS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03692	Collagen alpha-1	DEG_SCF_FBW7_1	534:541	LSGTPLVS	FBXW7	0.9877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons