DegronMD

Uniprot ID: Q9NWW0

Source protein: Host cell factor C1 regulator 1

Source gene: HCFC1R1

Class: LIG_APCC_ABBA_1

Location: 71:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8911

ASA_SCORE: 60.4167

COIL: 0.733

CONS_SCORE: 0.9329

DSS_SCORE: 0.4036

HELIX: 0.1035

FCONS_SCORE: 1.1174

RIG_SCORE: 0.6383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P83L	TCGA-CQ-6229	HNSC	TCGA	LSLHND	LIG_APCC_ABBA_1	0.1389
p.E61Q	TCGA-DK-A1A6	BLCA	TCGA	LSLHND	LIG_APCC_ABBA_1	0.0556
p.E61Q	DO472	BLCA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.0556
p.P85R	DO10044	COAD	ICGC	LSLHND	LIG_APCC_ABBA_1	0.0833
p.I70V	DO234183	ESAD	ICGC	LSLHND	LIG_APCC_ABBA_1	0.3056
p.R75S	DO228948	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.7427
p.P85T	DO228948	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.0833
p.P85T	DO229028	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.0833
p.P85T	DO229009	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.0833
p.P85T	NCI-H2023	lung	COSMIC	LSLHND	LIG_APCC_ABBA_1	0.0833
p.P85H	DO228974	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.0833
p.A73D	DO229045	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.7793
p.E72D	DO228904	LICA	ICGC	LSLHND	LIG_APCC_ABBA_1	0.6758
p.F66L	ACH-001610	Brain Cancer	CCLE	LSLHND	LIG_APCC_ABBA_1	0.1944
p.A63T	ACH-002026	Endometrial/Uterine Cancer	CCLE	LSLHND	LIG_APCC_ABBA_1	0.1111
p.L76V	A431	skin	COSMIC	LSLHND	LIG_APCC_ABBA_1	0.6765
p.P85S	Hs633T	soft_tissue	COSMIC	LSLHND	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NWW0	Host cell factor C1 regulator 1	LIG_APCC_ABBA_1	71:76	LSLHND	APC,CDC20,FZR1	0.8911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons