DegronMD

Uniprot ID: Q15562

Source protein: Transcriptional enhancer factor TEF-4

Source gene: TEAD2

Class: DEG_SCF_FBW7_1

Location: 187:194

E3 ligase: FBXW7

DEGRON score: 0.9703

ASA_SCORE: 62.075

COIL: 0.896

CONS_SCORE: 0.3942

DSS_SCORE: 0.6165

HELIX: 0.0431

FCONS_SCORE: 0.9612

RIG_SCORE: 0.6495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L193P	TCGA-DF-A2KN	UCEC	TCGA	LSLTPPST	DEG_SCF_FBW7_1	0.7582
p.L193P	DO223282	UCEC	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.7582
p.P196Q	TCGA-ER-A19C	SKCM	TCGA	LSLTPPST	DEG_SCF_FBW7_1	0.2778
p.P196Q	TCGA-FS-A1ZK	SKCM	TCGA	LSLTPPST	DEG_SCF_FBW7_1	0.2778
p.P196Q	DO37474	SKCM	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.2778
p.P196Q	DO47353	SKCM	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.2778
p.L200I	TCGA-FP-7829	STAD	TCGA	LSLTPPST	DEG_SCF_FBW7_1	0.1667
p.L200I	DO38308	STAD	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.1667
p.Y203H	DO222874	COCA	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.0833
p.Q186K	DO228976	LICA	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.3056
p.P183T	DO229211	THCA	ICGC	LSLTPPST	DEG_SCF_FBW7_1	0.2222
p.G184V	NCI-H1623	lung	COSMIC	LSLTPPST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15562	Transcriptional enhancer factor TEF-4	DEG_SCF_FBW7_1	187:194	LSLTPPST	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons