DegronMD

Uniprot ID: Q9UBY9

Source protein: Heat shock protein beta-7

Source gene: HSPB7

Class: LIG_APCC_ABBA_1

Location: 45:50

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6841

ASA_SCORE: 55.05

COIL: 0.5395

CONS_SCORE: 0.5989

DSS_SCORE: 0.532

HELIX: 0.4372

FCONS_SCORE: 1.0344

RIG_SCORE: 0.7183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L45M	TCGA-FS-A1ZB	SKCM	TCGA	LSMFSD	LIG_APCC_ABBA_1	0.5999
p.L45M	DO37886	SKCM	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.5999
p.D38N	TCGA-GN-A262	SKCM	TCGA	LSMFSD	LIG_APCC_ABBA_1	0.1389
p.D38N	DO37515	SKCM	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.1389
p.G53D	DO233103	GACA	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.25
p.E42K	DO45225	LIRI	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.25
p.P40S	DO233294	NACA	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.1944
p.D51G	DO232224	PBCA	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.3056
p.D51G	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LSMFSD	LIG_APCC_ABBA_1	0.3056
p.V53M	DO223286	UCEC	ICGC	LSMFSD	LIG_APCC_ABBA_1	0.25
p.P35R	ACH-002196	Lung Cancer	CCLE	LSMFSD	LIG_APCC_ABBA_1	0.0556
p.P35R	SBC-1	lung	COSMIC	LSMFSD	LIG_APCC_ABBA_1	0.0556
p.L45P	LS-411N	large_intestine	COSMIC	LSMFSD	LIG_APCC_ABBA_1	0.7582
p.D51N	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LSMFSD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBY9	Heat shock protein beta-7	LIG_APCC_ABBA_1	45:50	LSMFSD	APC,CDC20,FZR1	0.6841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons