DegronMD - Q9UBY9(HSPB7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R68C	TCGA-BR-8487	STAD	TCGA	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1389
p.S60L	TCGA-CN-4723	HNSC	TCGA	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.6556
p.S60L	DO14830	HNSC	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.6556
p.L45M	TCGA-FS-A1ZB	SKCM	TCGA	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation altering degron motif	0.5999
p.L45M	DO37886	SKCM	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation altering degron motif	0.5999
p.D38N	TCGA-GN-A262	SKCM	TCGA	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.1389
p.D38N	DO37515	SKCM	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.1389
p.R68H	TCGA-HT-A5RA	LGG	TCGA	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1389
p.S60W	DO48360	BLCA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.6763
p.G53D	DO233103	GACA	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.25
p.G53D	DO233103	GACA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.25
p.P62T	DO229022	LICA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.3056
p.S60N	DO50754	LICA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.5958
p.I71F	DO52266	LIHC	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.0556
p.E42K	DO45225	LIRI	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.25
p.P66S	DO222837	MELA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1944
p.P40S	DO233294	NACA	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.1944
p.D51G	DO232224	PBCA	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.3056
p.D51G	DO232224	PBCA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1944
p.D51G	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.3056
p.D51G	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1944
p.R57W	DO229221	THCA	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation altering degron motif	0.7523
p.V53M	DO223286	UCEC	ICGC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.25
p.V53M	DO223286	UCEC	ICGC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.25
p.G67E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1667
p.G67E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1667
p.G69V	SIDM00631	Breast Carcinoma	GDSC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1111
p.G69V	MDA-MB-330	breast	COSMIC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1111
p.P35R	ACH-002196	Lung Cancer	CCLE	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.0556
p.P35R	SBC-1	lung	COSMIC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.0556
p.L45P	LS-411N	large intestine	COSMIC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation altering degron motif	0.7582
p.D51N	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LSMFSD	LIG_APCC_ABBA_1	45:50	Mutation rewiring degron network	0.3056
p.D51N	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	MRPHSE	LIG_APCC_ABBA_1	56:61	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSPB7

UniProt ID: Q9UBY9

Entrez ID: 27129

Protein name: Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HSPB7 in