DegronMD

Uniprot ID: Q9UBY9

Source protein: Heat shock protein beta-7

Source gene: HSPB7

Class: LIG_APCC_ABBA_1

Location: 56:61

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5402

ASA_SCORE: 57.75

COIL: 0.8608

CONS_SCORE: 0.5974

DSS_SCORE: 0.4629

HELIX: 0.0848

FCONS_SCORE: 0.9828

RIG_SCORE: 0.6811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R68C	TCGA-BR-8487	STAD	TCGA	MRPHSE	LIG_APCC_ABBA_1	0.1389
p.S60L	TCGA-CN-4723	HNSC	TCGA	MRPHSE	LIG_APCC_ABBA_1	0.6556
p.S60L	DO14830	HNSC	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.6556
p.R68H	TCGA-HT-A5RA	LGG	TCGA	MRPHSE	LIG_APCC_ABBA_1	0.1389
p.S60W	DO48360	BLCA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.6763
p.G53D	DO233103	GACA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.25
p.P62T	DO229022	LICA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.3056
p.S60N	DO50754	LICA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.5958
p.I71F	DO52266	LIHC	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.0556
p.P66S	DO222837	MELA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.1944
p.D51G	DO232224	PBCA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.1944
p.D51G	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	MRPHSE	LIG_APCC_ABBA_1	0.1944
p.R57W	DO229221	THCA	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.7523
p.V53M	DO223286	UCEC	ICGC	MRPHSE	LIG_APCC_ABBA_1	0.25
p.G67E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MRPHSE	LIG_APCC_ABBA_1	0.1667
p.G67E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	MRPHSE	LIG_APCC_ABBA_1	0.1667
p.G69V	SIDM00631	Breast Carcinoma	GDSC	MRPHSE	LIG_APCC_ABBA_1	0.1111
p.G69V	MDA-MB-330	breast	COSMIC	MRPHSE	LIG_APCC_ABBA_1	0.1111
p.D51N	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	MRPHSE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBY9	Heat shock protein beta-7	LIG_APCC_ABBA_1	56:61	MRPHSE	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons